Antibacterial and Antibiofilm Effects of Allelopathic Compounds Identified in Medicago sativa L. Seedling Exudate against Escherichia coli

In this study, the allelopathic properties of L. (alfalfa) seedling exudates on the germination of seeds of various species were investigated. The compounds responsible for the allelopathic effects of alfalfa were identified and characterized by employing liquid chromatography ion mobility high-reso...

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Published inMolecules (Basel, Switzerland) Vol. 28; no. 6; p. 2645
Main Authors Abouzeid, Sara, Beutling, Ulrike, Elekhnawy, Engy, Selmar, Dirk
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 14.03.2023
MDPI
Subjects
Alfalfa
alfalfa seed exudates
allelopathic
Allelopathy
Antibacterial activity
Antimicrobial activity
Barley
Biofilms
Canavanine
Canavanine - analysis
Canavanine - pharmacology
dipeptides
E coli
Escherichia coli
Exudates
Exudates and Transudates
Exudation
Flavonoids
Flowers & plants
Food contamination & poisoning
Gene expression
Germination
hyperoside
Ionic mobility
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Medicago sativa
Medicago sativa - chemistry
Minimum inhibitory concentration
Pathogens
Plant species
Scientific imaging
Seedlings
Seeds
Seeds - chemistry
dipeptides
allelopathic
hyperoside
flavonoids
canavanine
alfalfa seed exudates
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Abstract In this study, the allelopathic properties of L. (alfalfa) seedling exudates on the germination of seeds of various species were investigated. The compounds responsible for the allelopathic effects of alfalfa were identified and characterized by employing liquid chromatography ion mobility high-resolution mass spectrometry. Crude exudates inhibited the germination of seeds of all various plant species tested. Overall, nine compounds in alfalfa were identified and quantified. The most predominant compounds were a hyperoside representing a flavonoid glucoside, the non-proteinogenic amino acid canavanine, and two dipeptides, identified as H-Glu-Tyr-OH and H-Phe-Glu-OH. The latter corresponds to the first finding that dipeptides are exuded from alfalfa seedlings. In addition, the antibacterial and antibiofilm activities of alfalfa exudate and its identified compounds were elucidated. Both hyperoside and canavanine revealed the best antibacterial activity with minimum inhibitory concentration (MIC) values that ranged from 8 to 32 and 32 to 256 µg/mL, respectively. Regarding the antibiofilm action, hyperoside and canavanine caused a decline in the percentage of isolates that possessed a strong and moderate biofilm-forming potential from 68.42% to 21.05% and 31.58%, respectively. Studies on their inhibiting effects exhibit that these major substances are predominantly responsible for the allelopathic and antimicrobial effects of the crude exudates.
AbstractList In this study, the allelopathic properties of Medicago sativa L. (alfalfa) seedling exudates on the germination of seeds of various species were investigated. The compounds responsible for the allelopathic effects of alfalfa were identified and characterized by employing liquid chromatography ion mobility high-resolution mass spectrometry. Crude exudates inhibited the germination of seeds of all various plant species tested. Overall, nine compounds in alfalfa were identified and quantified. The most predominant compounds were a hyperoside representing a flavonoid glucoside, the non-proteinogenic amino acid canavanine, and two dipeptides, identified as H-Glu-Tyr-OH and H-Phe-Glu-OH. The latter corresponds to the first finding that dipeptides are exuded from alfalfa seedlings. In addition, the antibacterial and antibiofilm activities of alfalfa exudate and its identified compounds were elucidated. Both hyperoside and canavanine revealed the best antibacterial activity with minimum inhibitory concentration (MIC) values that ranged from 8 to 32 and 32 to 256 µg/mL, respectively. Regarding the antibiofilm action, hyperoside and canavanine caused a decline in the percentage of E. coli isolates that possessed a strong and moderate biofilm-forming potential from 68.42% to 21.05% and 31.58%, respectively. Studies on their inhibiting effects exhibit that these major substances are predominantly responsible for the allelopathic and antimicrobial effects of the crude exudates.
In this study, the allelopathic properties of Medicago sativa L. (alfalfa) seedling exudates on the germination of seeds of various species were investigated. The compounds responsible for the allelopathic effects of alfalfa were identified and characterized by employing liquid chromatography ion mobility high-resolution mass spectrometry. Crude exudates inhibited the germination of seeds of all various plant species tested. Overall, nine compounds in alfalfa were identified and quantified. The most predominant compounds were a hyperoside representing a flavonoid glucoside, the non-proteinogenic amino acid canavanine, and two dipeptides, identified as H-Glu-Tyr-OH and H-Phe-Glu-OH. The latter corresponds to the first finding that dipeptides are exuded from alfalfa seedlings. In addition, the antibacterial and antibiofilm activities of alfalfa exudate and its identified compounds were elucidated. Both hyperoside and canavanine revealed the best antibacterial activity with minimum inhibitory concentration (MIC) values that ranged from 8 to 32 and 32 to 256 µg/mL, respectively. Regarding the antibiofilm action, hyperoside and canavanine caused a decline in the percentage of E. coli isolates that possessed a strong and moderate biofilm-forming potential from 68.42% to 21.05% and 31.58%, respectively. Studies on their inhibiting effects exhibit that these major substances are predominantly responsible for the allelopathic and antimicrobial effects of the crude exudates.
In this study, the allelopathic properties of L. (alfalfa) seedling exudates on the germination of seeds of various species were investigated. The compounds responsible for the allelopathic effects of alfalfa were identified and characterized by employing liquid chromatography ion mobility high-resolution mass spectrometry. Crude exudates inhibited the germination of seeds of all various plant species tested. Overall, nine compounds in alfalfa were identified and quantified. The most predominant compounds were a hyperoside representing a flavonoid glucoside, the non-proteinogenic amino acid canavanine, and two dipeptides, identified as H-Glu-Tyr-OH and H-Phe-Glu-OH. The latter corresponds to the first finding that dipeptides are exuded from alfalfa seedlings. In addition, the antibacterial and antibiofilm activities of alfalfa exudate and its identified compounds were elucidated. Both hyperoside and canavanine revealed the best antibacterial activity with minimum inhibitory concentration (MIC) values that ranged from 8 to 32 and 32 to 256 µg/mL, respectively. Regarding the antibiofilm action, hyperoside and canavanine caused a decline in the percentage of isolates that possessed a strong and moderate biofilm-forming potential from 68.42% to 21.05% and 31.58%, respectively. Studies on their inhibiting effects exhibit that these major substances are predominantly responsible for the allelopathic and antimicrobial effects of the crude exudates.
Author Abouzeid, Sara
Beutling, Ulrike
Selmar, Dirk
Elekhnawy, Engy
AuthorAffiliation 3 Department of Chemical Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany; ulrike.beutling@helmholtz-hzi.de
4 Pharmaceutical Microbiology Department, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt; engy.ali@pharm.tanta.edu.eg
1 Institute for Plant Biology, TU Braunschweig, 38106 Braunschweig, Germany; d.selmar@tu-bs.de
2 Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
AuthorAffiliation_xml – name: 1 Institute for Plant Biology, TU Braunschweig, 38106 Braunschweig, Germany; d.selmar@tu-bs.de
– name: 2 Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
– name: 3 Department of Chemical Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany; ulrike.beutling@helmholtz-hzi.de
– name: 4 Pharmaceutical Microbiology Department, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt; engy.ali@pharm.tanta.edu.eg
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  fullname: Selmar, Dirk
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36985619$$D View this record in MEDLINE/PubMed
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Keywords dipeptides
allelopathic
hyperoside
flavonoids
canavanine
alfalfa seed exudates
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SSID ssj0021415
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Snippet In this study, the allelopathic properties of L. (alfalfa) seedling exudates on the germination of seeds of various species were investigated. The compounds...
In this study, the allelopathic properties of Medicago sativa L. (alfalfa) seedling exudates on the germination of seeds of various species were investigated....
In this study, the allelopathic properties of Medicago sativa L. (alfalfa) seedling exudates on the germination of seeds of various species were investigated....
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SourceType Open Website
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Aggregation Database
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StartPage 2645
SubjectTerms Alfalfa
alfalfa seed exudates
allelopathic
Allelopathy
Antibacterial activity
Antimicrobial activity
Barley
Biofilms
Canavanine
Canavanine - analysis
Canavanine - pharmacology
dipeptides
E coli
Escherichia coli
Exudates
Exudates and Transudates
Exudation
Flavonoids
Flowers & plants
Food contamination & poisoning
Gene expression
Germination
hyperoside
Ionic mobility
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Medicago sativa
Medicago sativa - chemistry
Minimum inhibitory concentration
Pathogens
Plant species
Scientific imaging
Seedlings
Seeds
Seeds - chemistry
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Title Antibacterial and Antibiofilm Effects of Allelopathic Compounds Identified in Medicago sativa L. Seedling Exudate against Escherichia coli
URI https://www.ncbi.nlm.nih.gov/pubmed/36985619
https://www.proquest.com/docview/2791679246
https://search.proquest.com/docview/2792509416
https://pubmed.ncbi.nlm.nih.gov/PMC10056293
https://doaj.org/article/165167b564564e69803c58ae5e25842e
Volume 28
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