NMR-based metabolomics approach to study the toxicity of lambda-cyhalothrin to goldfish (Carassius auratus)

• Published in: Aquatic toxicology Vol. 146; pp. 82 - 92
• Main Authors: Li, Minghui, Wang, Junsong, Lu, Zhaoguang, Wei, Dandan, Yang, Minghua, Kong, Lingyi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.01.2014; Elsevier
• Subjects: 1H NMR spectroscopy; Agnatha. Pisces; alanine; Animal, plant and microbial ecology; Animals; Applied ecology; aquatic environment; Behavior, Animal - drug effects; Biological and medical sciences; biomarkers; brain; Brain - drug effects; Carassius auratus; choline; discriminant analysis; Ecotoxicology, biological effects of pollution; Effects of pollution and side effects of pesticides on vertebrates; energy; Energy Metabolism - drug effects; Freshwater; Fundamental and applied biological sciences. Psychology; goldfish; Goldfish (Carassius auratus); Goldfish - metabolism; Goldfish - physiology; heart; Heart - drug effects; isoleucine; Kidney - drug effects; kidneys; lactic acid; Lambda-cyhalothrin; least squares; leucine; liver; Liver - drug effects; Magnetic Resonance Spectroscopy; metabolites; Metabolomics; myo-inositol; neurotransmitters; Nitriles - toxicity; nuclear magnetic resonance spectroscopy; oxidative stress; Oxidative Stress - drug effects; phosphocreatine; pollution; Pyrethrins - toxicity; Synaptic Transmission - drug effects; taurine; tissues; toxicity; valine; Water Pollutants, Chemical - toxicity; Metabolomics; Goldfish (Carassius auratus); 1H NMR spectroscopy; Lambda-cyhalothrin; Insecticide; Metabolite; Toxicity; Pesticides; Pyrethroids; NMR spectrometry; Two dimension spectrometry; Hydrogen 1; Freshwater environment; H NMR spectroscopy; Pollutant; Tissue; Vertebrata; Carassius auratus; Histopathology; Pisces

•A goldfish model was established to investigate the toxicity of lambda-cyhalothrin (LCT) exposure on multiple organs.•NMR based metabolomics approach were firstly used to provide a global view of the toxicity of LCT.•LCT induced neurotransmitters and osmoregulatory imbalances, oxidative stress, ene...