Behavioral changes as the earliest clinical manifestation of progressive supranuclear palsy

The clinical and pathological heterogeneity of progressive supranuclear palsy (PSP) is well established. Even with a well-defined clinical phenotype and a thorough laboratory workup, PSP can be misdiagnosed, especially in its early stages. A 52-year-old woman, who we initially diagnosed with a behav...

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Published inJournal of clinical neurology (Seoul, Korea) Vol. 6; no. 3; pp. 148 - 151
Main Authors Han, Hyun Jeong, Kim, Hyeyun, Park, Jong-Ho, Shin, Hyung-Woo, Kim, Go Un, Kim, Dong Sun, Lee, Eun Ja, Oh, Hwa Eun, Park, Seung-Hye, Kim, Yun Jung
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Neurological Association 01.09.2010
대한신경과학회
Subjects
Case Report
신경과학
parkinsonism
frontotemporal dementia
progressive supranuclear palsy
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Summary:The clinical and pathological heterogeneity of progressive supranuclear palsy (PSP) is well established. Even with a well-defined clinical phenotype and a thorough laboratory workup, PSP can be misdiagnosed, especially in its early stages. A 52-year-old woman, who we initially diagnosed with a behavioral variant of frontotemporal dementia developed parkinsonian features, which then progressed to gait instability and gaze abnormality. We report herein a pathologically confirmed case of PSP presenting with behavioral changes including agitation and irritability, which eventually led to the cardinal symptoms of progressive supranuclear palsy.
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G704-002236.2010.6.3.007
ISSN:1738-6586
2005-5013
DOI:10.3988/jcn.2010.6.3.148