Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids

• Published in: Journal of allergy and clinical immunology Vol. 143; no. 1; pp. 104 - 113.e14
• Main Authors: Peters, Michael C., Kerr, Sheena, Dunican, Eleanor M., Woodruff, Prescott G., Fajt, Merritt L., Levy, Bruce D., Israel, Elliot, Phillips, Brenda R., Mauger, David T., Comhair, Suzy A., Erzurum, Serpil C., Johansson, Mats W., Jarjour, Nizar N., Coverstone, Andrea M., Castro, Mario, Hastie, Annette T., Bleecker, Eugene R., Wenzel, Sally E., Fahy, John V.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019; Elsevier Limited
• Subjects: Administration, Inhalation; Adrenal Cortex Hormones - administration & dosage; Adult; Age; Asthma; Asthma - blood; Asthma - drug therapy; Asthma - immunology; Biomarkers; Biomarkers - blood; Blood levels; Body mass index; Body weight; Corticosteroids; Cytokines; Cytokines - blood; Cytokines - immunology; Eosinophils - immunology; Eosinophils - metabolism; Eosinophils - pathology; Family medical history; Female; Gene expression; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; Health care; Humans; Immunoglobulin E; Immunoglobulin E - blood; Immunoglobulin E - immunology; Immunomodulators; Inflammation; Inflammation - blood; Inflammation - immunology; Leukocyte Count; Leukocytes (eosinophilic); Longitudinal Studies; Male; Middle Aged; Patients; Respiratory tract; Severe asthma; Sputum; steroid resistance; Th2 Cells - immunology; Th2 Cells - metabolism; type 2 inflammation; Values; steroid resistance; Feno; stT2-low; T2GM; biomarkers; ROC; SARP; AUC; CT; RIN; OLS; ICS; Severe asthma; type 2 inflammation; srT2-high; BMI

Airway type 2 inflammation is usually corticosteroid sensitive, but the role of type 2 inflammation as a mechanism of asthma in patients receiving high-dose inhaled corticosteroids (ICSs) is uncertain. We sought to determine whether airway type 2 inflammation persists in patients treated with ICSs a...