Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids - Peters, Michael C.; Kerr, Sheena; Dunican, Eleanor M.; Woodruff, Prescott G.; Fajt, Merritt L.; Levy, Bruce D.; Israel, Elliot; Phillips, Brenda R.; Mauger, David T.; Comhair, Suzy A.; Erzurum, Serpil C.; Johansson, Mats W.; et al. (Journal of allergy and clinical immunology, 2019)
Keywords: Administration, Inhalation; Adrenal Cortex Hormones - administration & dosage; Adult; Age; Asthma; Asthma - blood; Asthma - drug therapy; Asthma - immunology; Biomarkers; Biomarkers - blood; Blood levels; Body mass index; Body weight; Corticosteroids; Cytokines; Cytokines - blood; Cytokines - immunology; Eosinophils - immunology; Eosinophils - metabolism; Eosinophils - pathology; Family medical history; Female; Gene expression; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; Health care; Humans; Immunoglobulin E; Immunoglobulin E - blood; Immunoglobulin E - immunology; Immunomodulators; Inflammation; Inflammation - blood; Inflammation - immunology; Leukocyte Count; Leukocytes (eosinophilic); Longitudinal Studies; Male; Middle Aged; Patients; Respiratory tract; Severe asthma; Sputum; steroid resistance; Th2 Cells - immunology; Th2 Cells - metabolism; type 2 inflammation; Values; steroid resistance; Feno; stT2-low; T2GM; biomarkers; ROC; SARP; AUC; CT; RIN; OLS; ICS; Severe asthma; type 2 inflammation; srT2-high; BMI