A Promising Hepatocyte-Like Cell Line, CCL-13, Exhibits Good Liver Function Both In Vitro and in an Acute Liver Failure Model

• Published in: Transplantation proceedings Vol. 45; no. 2; pp. 688 - 694
• Main Authors: Yang, T., Li, C., Zhang, L., Li, M., Zhou, P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2013
• Subjects: Animals; Biomarkers - metabolism; Blotting, Western; Cell Line, Tumor; Cell Shape; Disease Models, Animal; Feasibility Studies; Gene Expression Regulation; Hepatectomy; Hepatocytes - metabolism; Hepatocytes - pathology; Hepatocytes - transplantation; Humans; Liver - metabolism; Liver - pathology; Liver - physiopathology; Liver Failure, Acute - etiology; Liver Failure, Acute - metabolism; Liver Failure, Acute - pathology; Liver Failure, Acute - surgery; Liver, Artificial; Male; Mice; Mice, Nude; Microscopy, Confocal; Phenotype; Rats; Rats, Sprague-Dawley; Recovery of Function; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Surgery; Time Factors

A great many patients awaiting liver transplantation die because of the shortage of donor livers. To resolve the problem, liver support systems like bioartificial livers (BALs) have become subjects of active investigation. However, the problem with BALs is that it is difficult to find a source of he...