SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis

• Published in: The Journal of biological chemistry Vol. 296; p. 100306
• Main Authors: Bayati, Armin, Kumar, Rahul, Francis, Vincent, McPherson, Peter S.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.01.2021; American Society for Biochemistry and Molecular Biology
• Subjects: clathrin; COVID-19; dynamin; endocytosis; infection; SARS-CoV-2; virus entry; TfR; infection; clathrin; SARS-CoV; MERS-CoV; CQ; dynamin; COVID-19; ACE2; SARS-CoV-2; Tf; virus entry; endocytosis; CHC

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, so understanding its biology and infection mechanisms is critical to facing this major medical challenge. SARS-CoV-2 is known to use its spike glycoprotein to interact with the cell surface as a first st...