Differential modulation of gene expression in the NMDA postsynaptic density of schizophrenic and control smokers

• Published in: Brain research. Molecular brain research. Vol. 139; no. 2; pp. 317 - 332
• Main Authors: Mexal, S., Frank, M., Berger, R., Adams, C.E., Ross, R.G., Freedman, R., Leonard, S.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 03.10.2005; Elsevier
• Subjects: Adult and adolescent clinical studies; Aged; alpha Catenin - metabolism; Analysis of Variance; Biological and medical sciences; Blotting, Northern - methods; Blotting, Western - methods; Female; Fundamental and applied biological sciences. Psychology; Gene Expression - physiology; Glutamate; Humans; Immune system; Male; Medical sciences; Microarray; Microarray Analysis - methods; Middle Aged; Models, Biological; Nicotine; Nicotinic receptor; NMDA postsynaptic density; Postmortem brain; Postmortem Changes; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Receptors, N-Methyl-D-Aspartate - genetics; Receptors, N-Methyl-D-Aspartate - metabolism; Reverse Transcriptase Polymerase Chain Reaction - methods; RNA, Messenger - biosynthesis; Schizophrenia; Schizophrenia - metabolism; Schizophrenia - physiopathology; Smoking; Smoking - metabolism; Smoking - physiopathology; Vertebrates: nervous system and sense organs; Schizophrenia; Microarray; Glutamate; Nicotinic receptor; Postmortem brain; NMDA postsynaptic density; Nicotine; Smoking; Immune system; Central nervous system; Postmortem; Tobacco smoking; Gene expression; Encephalon; Psychosis; Cholinergic receptor; Excitatory aminoacid; Neurotransmitter; NMDA; Postsynaptic density

Nicotine is known to induce the release of multiple neurotransmitters, including glutamate and dopamine, through activation of nicotinic receptors. Gene expression in the N-methyl- d-aspartate postsynaptic density (NMDA-PSD), as well as other functional groups, was compared in postmortem hippocampus...