Sphingolipid metabolism-related genes as diagnostic markers in pneumonia-induced sepsis: the AUG model

• Published in: Scientific reports Vol. 15; no. 1; pp. 17552 - 14
• Main Authors: Wu, Jing, Li, Xiaomin, Chen, Zhihao, Lin, Yiting, Long, Qiuyue, Jiang, Mingzheng, Hu, Xiaoyi, Song, Shixu, Ye, Hongli, Li, Jiwei, Wu, Fangfang, Zheng, Jianshi, Wang, Minghui, Gao, Zhancheng, Ning, Pu, Zheng, Yali
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.05.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 692/53; 692/699/1785; 692/699/255; Aged; Apoptosis; Autophagy; Biomarkers - metabolism; Case-Control Studies; Cell death; Cell fate; Cell interactions; Ceramide; Female; Gene Expression Profiling; Humanities and Social Sciences; Humans; Immune response; Leukocyte migration; Lipid metabolism; Macrophage migration inhibitory factor; Macrophage Migration-Inhibitory Factors - metabolism; Male; Metabolism; Middle Aged; MIF signaling; multidisciplinary; Peripheral blood; Pneumonia; Pneumonia - complications; Pneumonia - genetics; Pneumonia-induced sepsis; Prediction models; Prognosis; Programmed cell death; Science; Science (multidisciplinary); Sepsis; Sepsis - diagnosis; Sepsis - etiology; Sepsis - genetics; Sepsis - metabolism; Sphingolipid metabolism; Sphingolipids - metabolism; Therapeutic targets; Transcriptome; Transcriptomes; Programmed cell death; Sphingolipid metabolism; MIF signaling; Pneumonia-induced sepsis

Pneumonia-induced sepsis (PIS) is a life-threatening condition with high mortality rates, necessitating the identification of biomarkers and therapeutic targets. Sphingolipid, particularly ceramides, are pivotal in modulating immune responses and determining cell fate. In this study, we identified a...