Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD

• Published in: Respiratory research Vol. 17; no. 1; p. 84
• Main Authors: Hollins, Fay, Sutcliffe, Amanda, Gomez, Edith, Berair, Rachid, Russell, Richard, Szyndralewiez, Cédric, Saunders, Ruth, Brightling, Christopher
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.07.2016; BioMed Central
• Subjects: Asthma; Bronchi - drug effects; Bronchi - enzymology; Bronchi - physiopathology; Care and treatment; Case-Control Studies; Cells, Cultured; Chronic obstructive pulmonary disease; Complications and side effects; Enzyme Inhibitors - pharmacology; Humans; Hydrogen peroxide; Influence; Letter to the Editor; Lung diseases, Obstructive; Muscle, Smooth - drug effects; Muscle, Smooth - enzymology; Muscle, Smooth - physiopathology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - enzymology; NADPH Oxidase 4 - antagonists & inhibitors; NADPH Oxidase 4 - metabolism; Oxidative stress; Oxidizing agents; Oxygen; Pulmonary Disease, Chronic Obstructive - enzymology; Pulmonary Disease, Chronic Obstructive - etiology; Pulmonary Disease, Chronic Obstructive - physiopathology; Reactive oxygen species; Reactive Oxygen Species - metabolism; Smoking - adverse effects; Smooth muscle; Tumor Necrosis Factor-alpha - pharmacology; Up-Regulation; Oxidative stress; NOX4; Reactive oxygen species; Airway smooth muscle; COPD

The burden of oxidative stress is increased in chronic obstructive pulmonary disease (COPD). However, whether the intra-cellular mechanisms controlling the oxidant/anti-oxidant balance in structural airway cells such as airway smooth muscle in COPD is altered is unclear. We sought to determine wheth...