Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD - Hollins, Fay; Sutcliffe, Amanda; Gomez, Edith; Berair, Rachid; Russell, Richard; Szyndralewiez, Cédric; Saunders, Ruth; Brightling, Christopher (Respiratory research, 2016)
Keywords: Asthma; Bronchi - drug effects; Bronchi - enzymology; Bronchi - physiopathology; Care and treatment; Case-Control Studies; Cells, Cultured; Chronic obstructive pulmonary disease; Complications and side effects; Enzyme Inhibitors - pharmacology; Humans; Hydrogen peroxide; Influence; Letter to the Editor; Lung diseases, Obstructive; Muscle, Smooth - drug effects; Muscle, Smooth - enzymology; Muscle, Smooth - physiopathology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - enzymology; NADPH Oxidase 4 - antagonists & inhibitors; NADPH Oxidase 4 - metabolism; Oxidative stress; Oxidizing agents; Oxygen; Pulmonary Disease, Chronic Obstructive - enzymology; Pulmonary Disease, Chronic Obstructive - etiology; Pulmonary Disease, Chronic Obstructive - physiopathology; Reactive oxygen species; Reactive Oxygen Species - metabolism; Smoking - adverse effects; Smooth muscle; Tumor Necrosis Factor-alpha - pharmacology; Up-Regulation; Oxidative stress; NOX4; Reactive oxygen species; Airway smooth muscle; COPD