Nasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study

• Published in: Journal of inflammation (London, England) Vol. 13; no. 1; p. 26
• Main Authors: Poletti, Donatella, Iannini, Valeria, Casolari, Paolo, Contoli, Marco, Papi, Alberto, Kirkham, Paul, Hansel, Trevor T., Chung, Kian Fan, Barnes, Peter J., Pastore, Antonio, Pelucchi, Stefano, Adcock, Ian M., Caramori, Gaetano
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.08.2016; BioMed Central
• Subjects: Analysis; Care and treatment; Corticosteroids; Dosage and administration; Inflammation; Quality of life; Rhinitis; Risk factors; Symptomatology; Nasal inflammation; Goblet cells; Nasal epithelial cells; Non-allergic rhinitis; Nasal scraping; MUC5AC; p65; Eosinophils

The pathogenesis of non-allergic rhinitis (NAR) is still largely unknown. Furthermore, it is unclear whether there is a correlation between the effect of nasal glucocorticoids on nasal inflammation and on nasal symptoms and quality of life. In this pilot study we recruited 12 healthy subjects and 24...