Influence of type 2 diabetes on local production of inflammatory molecules in adults with and without chronic periodontitis: a cross-sectional study

• Published in: BMC oral health Vol. 15; no. 1; p. 86
• Main Authors: Mohamed, Hasaan G., Idris, Shaza B., Ahmed, Mutaz F., Åstrøm, Anne N., Mustafa, Kamal, Ibrahim, Salah O., Mustafa, Manal
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.07.2015; BioMed Central
• Subjects: Adult; Aged; Chemokine CCL3 - analysis; Chemokine CCL4 - analysis; Chemokine CCL5 - analysis; Chronic Periodontitis - blood; Chronic Periodontitis - immunology; Cross-Sectional Studies; Dental Plaque Index; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - immunology; Female; Fibroblast Growth Factors - analysis; Gingival Crevicular Fluid - immunology; Glycated Hemoglobin A - analysis; Glycosylated hemoglobin; Granulocyte Colony-Stimulating Factor - analysis; Humans; Inflammation; Inflammation Mediators - analysis; Inflammation Mediators - blood; Interferon-gamma - analysis; Interleukin-10 - analysis; Interleukin-4 - analysis; Interleukin-6 - analysis; Interleukin-7 - analysis; Interleukin-8 - analysis; Male; Middle Aged; Periodontal Index; Periodontitis; Physiological aspects; Th1 Cells - immunology; Th2 Cells - immunology; Tumor Necrosis Factor-alpha - analysis; Type 2 diabetes; Vascular Endothelial Growth Factor A - analysis; Young Adult; Sudan
• ISSN: 1472-6831; 1472-6831
• DOI: 10.1186/s12903-015-0073-z

Pathological changes in periodontal tissues are mediated by the interaction between microorganisms and the host immune-inflammatory response. Hyperglycemia may interfere with this process. The aim of this study was to compare the levels of 27 inflammatory molecules in the gingival crevicular fluid (...