Systemic metoclopramide to prevent postoperative nausea and vomiting: a meta-analysis without Fujii’s studies

• Published in: British journal of anaesthesia : BJA Vol. 109; no. 5; pp. 688 - 697
• Main Authors: De Oliveira, G.S., Castro-Alves, L.J., Chang, R, Yaghmour, E, McCarthy, R.J.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.11.2012; Oxford University Press
• Subjects: anaesthesia, general; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antiemetics - therapeutic use; Biological and medical sciences; Humans; Medical sciences; Metoclopramide - therapeutic use; PONV; Postoperative Nausea and Vomiting - prevention & control; premedication, metoclopramide; Randomized Controlled Trials as Topic; anaesthesia, general; PONV; premedication, metoclopramide; Postoperative; Dopamine antagonist; Nausea; Metoclopramide; general; D2 Dopamine receptor; Vomiting; Benzamide derivatives; Digestive diseases; Anesthesia; premedication; Antiemetic; anaesthesia

Previous evidence suggested that 10 mg systemic metoclopramide is not effective to prevent postoperative nausea and/or vomiting (PONV) in patients receiving general anaesthesia. However, the evidence included data with questioned validity by the author Yoshitaka Fujii. The objective of the current s...