White matter microstructure abnormalities in thalassemia patients using TBSS analysis based on DTI

• Published in: Scientific reports Vol. 15; no. 1; pp. 17929 - 10
• Main Authors: Yang, Mingrui, Chen, Guowei, Luo, Chaotian, Tang, Cheng, Peng, Fei, Kong, Rong, Peng, Peng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.05.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1689; 692/308; 692/617/375/1345; Adolescent; Adult; Anisotropy; beta-Thalassemia - diagnostic imaging; beta-Thalassemia - pathology; Blood diseases; Case-Control Studies; Diffusion tensor imaging; Diffusion Tensor Imaging - methods; Female; Hemoglobinopathy; Humanities and Social Sciences; Humans; Iron overload; Magnetic resonance imaging; Male; Microstructural abnormalities; Middle Aged; multidisciplinary; Neuroimaging; ROC Curve; Science; Science (multidisciplinary); Spatial analysis; Statistical analysis; Substantia alba; Thalassemia; Tract-based spatial statistics; White matter; White Matter - diagnostic imaging; White Matter - pathology; Young Adult; Microstructural abnormalities; Iron overload; Thalassemia; Tract-based spatial statistics; White matter; Diffusion tensor imaging

Thalassemia is a hereditary hemoglobinopathy characterized by severe anemia and iron overload, which may affect brain microstructure. This study aims to investigate changes in the white matter (WM) microstructure of patients with β-thalassemia using diffusion tensor imaging (DTI) and tract-based spa...