High glucose levels promote glycolysis and cholesterol synthesis via ERRα and suppress the autophagy–lysosomal pathway in endometrial cancer

• Published in: Cell death & disease Vol. 16; no. 1; pp. 182 - 14
• Main Authors: Mao, Xiaodan, Huang, Lixiang, Liu, Xianhua, Lin, Xite, Wu, Qibin, Wang, Xinrui, Ren, Yuan, Ma, Jincheng, Zhang, Maotong, Lin, Yao, Ralser, Damian J., Mustea, Alexander, Chen, Gang, Sun, Pengming
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.03.2025; Springer Nature B.V; Nature Publishing Group
• Subjects: 101/28; 13/105; 13/2; 13/31; 13/51; 13/89; 631/67/2327; 692/699/2743/2037; 96/1; 96/34; Antibodies; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; Biochemistry; Biomedical and Life Sciences; Cancer; Carboplatin; Cell Biology; Cell Culture; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Cell viability; Cholecystokinin; Cholesterol; Cholesterol - biosynthesis; Diabetes mellitus; DNA sequencing; Endometrial cancer; Endometrial Neoplasms - genetics; Endometrial Neoplasms - metabolism; Endometrial Neoplasms - pathology; Endometrium; Enzymes; ERRalpha Estrogen-Related Receptor; Female; Flow cytometry; Glucose; Glucose - metabolism; Glucose - pharmacology; Glycolysis; Glycolysis - drug effects; Humans; Immunology; Life Sciences; Lipid metabolism; Lysosomes; Lysosomes - drug effects; Lysosomes - metabolism; Metabolism; Metabolites; Metformin; Molecular dynamics; Organoids; Prognosis; Receptors, Estrogen - genetics; Receptors, Estrogen - metabolism; Transmission electron microscopy; Uterine cancer

Endometrial cancer (EC) patients with Diabetes Mellitus (DM) always have a poor prognosis. Estrogen-related receptor α (ERRα) is known as the metabolic-related prognostic factor for EC. However, the mechanism linking glycolipid metabolism dysfunction mediated by ERRα to poor prognosis of EC with DM...