Flavonoids from the Roots of Sophora flavescens and Their Potential Anti-Inflammatory and Antiproliferative Activities

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 5; p. 2048
• Main Authors: Yang, Yan-Fei, Liu, Ting-Ting, Li, Guo-Xian, Chen, Xuan-Qin, Li, Rong-Tao, Zhang, Zhi-Jun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.02.2023; MDPI
• Subjects: Anti-Inflammatory Agents - pharmacology; antiproliferative; cyclohexanoid prenylflavonoids; Cytotoxicity; Flavonoids; Flavonoids - chemistry; Magnetic Resonance Spectroscopy; NO production inhibitory activity; Plant Extracts - pharmacology; Plant Roots - chemistry; Sophora - chemistry; Sophora flavescens; Spectrum analysis; NO production inhibitory activity; antiproliferative; flavonoids; cyclohexanoid prenylflavonoids; Sophora flavescens
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules28052048

The phytochemical investigation of the roots of the traditional Chinese medicinal plant Sophora flavescens led to the isolation of two novel prenylflavonoids with an unusual cyclohexyl substituent instead of the common aromatic ring B, named 4′,4′-dimethoxy-sophvein (17) and sophvein-4′-one (18), an...