Impaired adipose tissue lipid storage, but not altered lipolysis, contributes to elevated levels of NEFA in type 2 diabetes. Degree of hyperglycemia and adiposity are important factors

• Published in: Metabolism, clinical and experimental Vol. 65; no. 12; pp. 1768 - 1780
• Main Authors: Pereira, Maria J, Skrtic, Stanko, Katsogiannos, Petros, Abrahamsson, Niclas, Sidibeh, Cherno O, Dahgam, Santosh, Månsson, Marianne, Risérus, Ulf, Kullberg, Joel, Eriksson, Jan W
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2016
• Subjects: Adipose tissue; Adipose Tissue - metabolism; Adiposity; Aged; Case-Control Studies; Clinical Medicine; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; Fatty Acids, Nonesterified - blood; Female; Glycated Hemoglobin A - analysis; Humans; Hyperglycemia - diagnosis; Intra-Abdominal Fat; Klinisk medicin; Lipid Metabolism; Lipid storage; Lipolysis; Male; Metabolism; Middle Aged; Sex Factors; Type 2 diabetes; Type 2 diabetes; Adipose tissue; PDHA1; IRS1; MRI; SAT; T2D; Lipid storage; VAT; LPL; Metabolism; Lipolysis; ADRA2A; AT; FABP4; FASN; NEFA; GLUT4 and SLC2A4

Elevated levels of circulating non-esterified fatty acids (NEFA) mediate many adverse metabolic effects. In this work we aim to determine the impact of type 2 diabetes (T2D), glycemic control and obesity on lipolysis regulation. 20 control and 20 metformin-treated T2D subjects were matched for sex (...