Gene expression profiling in hypothalamus of immobilization-stressed mouse using cDNA microarray

To investigate the effects of repeated immobilization-stress challenge on HPA axis, genomic transcriptome in the hypothalamus of immobilization-stressed mouse was analyzed by using cDNA microarray. With the 1.5-fold cutoff of arbitrary criteria, the expression levels of 108 genes out of 6016 genes w...

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Published in	Brain research. Molecular brain research. Vol. 135; no. 1; pp. 293 - 300
Main Authors	Lee, Han-Chang, Chang, Dong-Eun, Yeom, Mijung, Kim, Gun-Ho, Choi, Kang-Duk, Shim, Insop, Lee, Hye-Jung, Hahm, Dae-Hyun
Format	Journal Article
Language	English
Published	Amsterdam Elsevier B.V 27.04.2005 Elsevier
Subjects	Animals Biological and medical sciences Body Weight - physiology cDNA microarray Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation - physiology Hypothalamus Hypothalamus - metabolism Immobilization Male Mice Mouse mRNA Oligonucleotide Array Sequence Analysis Restraint, Physical - physiology Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis Stress Time Factors Vertebrates: nervous system and sense organs Mouse Immobilization cDNA microarray mRNA Hypothalamus Gene expression Stress Rodentia Central nervous system Encephalon Vertebrata Mammalia Complementary DNA Animal
Online Access	Get full text
ISSN	0169-328X 1872-6941
DOI	10.1016/j.molbrainres.2004.11.016

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Abstract	To investigate the effects of repeated immobilization-stress challenge on HPA axis, genomic transcriptome in the hypothalamus of immobilization-stressed mouse was analyzed by using cDNA microarray. With the 1.5-fold cutoff of arbitrary criteria, the expression levels of 108 genes out of 6016 genes were significantly modulated in the hypothalamus by the stress. Energy metabolism-, lipid metabolism-, and apoptosis- and signal transduction-related genes were activated while DNA repair-, protein biosynthesis-, and structure integrity-related genes were down-regulated in the hypothalamus. Eighteen genes among them were selected for RT-PCR analysis to confirm the change of their expression levels on agarose gels. Besides, dozens of novel genes, which have not been previously reported, were screened to be modulated by the immobilization stress through the transcriptome analysis. These genes are related to apoptosis, tumor-suppression, DNA-binding and protein folding, and thus may be used as potential targets for the development of therapeutics of chronic stress or depressant.
AbstractList	To investigate the effects of repeated immobilization-stress challenge on HPA axis, genomic transcriptome in the hypothalamus of immobilization-stressed mouse was analyzed by using cDNA microarray. With the 1.5-fold cutoff of arbitrary criteria, the expression levels of 108 genes out of 6016 genes were significantly modulated in the hypothalamus by the stress. Energy metabolism-, lipid metabolism-, and apoptosis- and signal transduction-related genes were activated while DNA repair-, protein biosynthesis-, and structure integrity-related genes were down-regulated in the hypothalamus. Eighteen genes among them were selected for RT-PCR analysis to confirm the change of their expression levels on agarose gels. Besides, dozens of novel genes, which have not been previously reported, were screened to be modulated by the immobilization stress through the transcriptome analysis. These genes are related to apoptosis, tumor-suppression, DNA-binding and protein folding, and thus may be used as potential targets for the development of therapeutics of chronic stress or depressant. To investigate the effects of repeated immobilization-stress challenge on HPA axis, genomic transcriptome in the hypothalamus of immobilization-stressed mouse was analyzed by using cDNA microarray. With the 1.5-fold cutoff of arbitrary criteria, the expression levels of 108 genes out of 6016 genes were significantly modulated in the hypothalamus by the stress. Energy metabolism-, lipid metabolism-, and apoptosis- and signal transduction-related genes were activated while DNA repair-, protein biosynthesis-, and structure integrity-related genes were down-regulated in the hypothalamus. Eighteen genes among them were selected for RT-PCR analysis to confirm the change of their expression levels on agarose gels. Besides, dozens of novel genes, which have not been previously reported, were screened to be modulated by the immobilization stress through the transcriptome analysis. These genes are related to apoptosis, tumor-suppression, DNA-binding and protein folding, and thus may be used as potential targets for the development of therapeutics of chronic stress or depressant.To investigate the effects of repeated immobilization-stress challenge on HPA axis, genomic transcriptome in the hypothalamus of immobilization-stressed mouse was analyzed by using cDNA microarray. With the 1.5-fold cutoff of arbitrary criteria, the expression levels of 108 genes out of 6016 genes were significantly modulated in the hypothalamus by the stress. Energy metabolism-, lipid metabolism-, and apoptosis- and signal transduction-related genes were activated while DNA repair-, protein biosynthesis-, and structure integrity-related genes were down-regulated in the hypothalamus. Eighteen genes among them were selected for RT-PCR analysis to confirm the change of their expression levels on agarose gels. Besides, dozens of novel genes, which have not been previously reported, were screened to be modulated by the immobilization stress through the transcriptome analysis. These genes are related to apoptosis, tumor-suppression, DNA-binding and protein folding, and thus may be used as potential targets for the development of therapeutics of chronic stress or depressant.
Author	Hahm, Dae-Hyun Shim, Insop Chang, Dong-Eun Lee, Han-Chang Yeom, Mijung Lee, Hye-Jung Choi, Kang-Duk Kim, Gun-Ho
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Keywords	Mouse Immobilization cDNA microarray mRNA Hypothalamus Gene expression Stress Rodentia Central nervous system Encephalon Vertebrata Mammalia Complementary DNA Animal
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Snippet	To investigate the effects of repeated immobilization-stress challenge on HPA axis, genomic transcriptome in the hypothalamus of immobilization-stressed mouse...
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SubjectTerms	Animals Biological and medical sciences Body Weight - physiology cDNA microarray Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation - physiology Hypothalamus Hypothalamus - metabolism Immobilization Male Mice Mouse mRNA Oligonucleotide Array Sequence Analysis Restraint, Physical - physiology Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis Stress Time Factors Vertebrates: nervous system and sense organs
Title	Gene expression profiling in hypothalamus of immobilization-stressed mouse using cDNA microarray
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