In Vivo Evaluation of a Gastro-Resistant Enprotect® Capsule under Postprandial Conditions

• Published in: Pharmaceutics Vol. 15; no. 11; p. 2576
• Main Authors: Grimm, Michael, Rump, Adrian, Kromrey, Marie-Luise, Morof, Felix, Dumont, Camille, Jannin, Vincent, Tzvetkov, Mladen Vassilev, Weitschies, Werner
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2023
• Subjects: Acids; Caffeine; Capsules (Pharmacy); Chemical properties; Eating (Physiology); enteric hard capsule; Food; Gastric acid; hydroxypropyl methyl cellulose; hydroxypropyl methyl cellulose acetate succinate; Magnetic resonance imaging; MRI; Peptides; Pharmaceutical research; Physiological aspects; saliva; Scanners; Small intestine; Testing; Germany; France

Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel® Enprotect® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but robustness against postprandial intake needed to be proven. In...