A lesson for site-selective C-H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls

• Published in: Chemical science (Cambridge) Vol. 9; no. 1; pp. 22 - 32
• Main Authors: Hirano, Koji, Miura, Masahiro
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 07.01.2018
• Subjects: Chemistry; Natural products; Substrates

A 2-pyridone ring is a frequently occurring subunit in natural products, biologically active compounds, and pharmaceutical targets. Thus, the selective synthesis of substituted 2-pyridone derivatives through decoration and/or formation of pyridone rings has been one of the important longstanding sub...