Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study

• Published in: Discover. Oncology Vol. 16; no. 1; pp. 1343 - 18
• Main Authors: Zhao, Jiandong, Chen, Liwei, Han, Bing, Li, Siyang, Zhang, Yongxia, Gao, Ge, Liu, Jinjing
• Format: Journal Article
• Language: English
• Published: New York Springer US 16.07.2025; Springer Nature B.V; Springer
• Subjects: Analysis; Biomarkers; Cancer Research; Disease; Ferroptosis; Genomes; Head & neck cancer; Homeostasis; Hypopharyngeal cancer; Internal Medicine; Iron; Iron metabolism; Laryngeal cancer; Larynx; Medicine; Medicine & Public Health; Mendelian randomization; Metabolism; Metastasis; Mitochondrial function; Molecular Medicine; Oncology; Pathogenesis; Radiotherapy; Research methodology; Risk factors; Sirtuin-5; Statistics; Surgical Oncology; Tumorigenesis; Variables; Laryngeal cancer; Hypopharyngeal cancer; Iron metabolism; Mendelian randomization; Sirtuin-5; Mitochondrial function

Background This Mendelian randomization (MR) study aimed to investigate bidirectional causal relationships between genetically predicted iron homeostasis, mitochondrial function, and the risk of laryngeal and hypopharyngeal cancers. Methods Summary-level data were extracted from genome-wide associat...