A Multilevel Functional Study of a SNAP25 At-Risk Variant for Bipolar Disorder and Schizophrenia

• Published in: The Journal of neuroscience Vol. 37; no. 43; pp. 10389 - 10397
• Main Authors: Houenou, Josselin, Boisgontier, Jennifer, Henrion, Annabelle, d'Albis, Marc-Antoine, Dumaine, Anne, Linke, Julia, Wessa, Michèle, Daban, Claire, Hamdani, Nora, Delavest, Marine, Llorca, Pierre-Michel, Lançon, Christophe, Schürhoff, Franck, Szöke, Andrei, Le Corvoisier, Philippe, Barau, Caroline, Poupon, Cyril, Etain, Bruno, Leboyer, Marion, Jamain, Stéphane
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 25.10.2017
• Subjects: Adult; Age; Alleles; Amygdala; Animals; Attention deficit hyperactivity disorder; Bipolar disorder; Bipolar Disorder - diagnostic imaging; Bipolar Disorder - genetics; Cell Line, Tumor; Cognitive science; Cognitive Sciences; Developmental plasticity; Docking; Female; Females; Gene expression; Genetic Predisposition to Disease - genetics; Genetic Variation - genetics; Genetics; Humans; Hyperactivity; Life Sciences; Limbic System - diagnostic imaging; Magnetic Resonance Imaging - methods; Male; Males; Mental disorders; Mice; Middle Aged; Nerve Net - diagnostic imaging; Neural networks; Neurobiology; Neuroimaging; Neurons and Cognition; Neuroscience; Prefrontal cortex; Prefrontal Cortex - diagnostic imaging; Proteins; Psychology and behavior; Risk; Schizophrenia; Schizophrenia - diagnostic imaging; Schizophrenia - genetics; SNAP-25 protein; Synaptosomal-Associated Protein 25 - genetics; Transcription; Young Adult; brain imaging; SNAP25; bipolar disorder; genetics; schizophrenia; SNARE

The synaptosomal-associated protein SNAP25 is a key player in synaptic vesicle docking and fusion and has been associated with multiple psychiatric conditions, including schizophrenia, bipolar disorder, and attention-deficit/hyperactivity disorder. We recently identified a promoter variant in SNAP25...