Cell division cycle protein 42-driven activation of the MKK3/6-p38 signaling pathway participates in cardiac remodeling in mice

• Published in: Cellular and molecular life sciences : CMLS Vol. 82; no. 1; pp. 269 - 16
• Main Authors: Wen, Ke, Xie, Lin, Liu, Quan-Wen, Yu, Guan-Hui, Qiao, Xu-Hui, Huang, Yu-Chun, Wang, Lu, Li, Xin, Wen, Li-Dan, Wang, Xiao-Lei, He, Jing, Xiao, Xin-Yu, Zhao, Xiao-Xiao, Wang, Ling-Fang, Xin, Hong-Bo, Deng, Ke-Yu
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 03.07.2025; Springer Nature B.V; Springer
• Subjects: Angiotensin II; Angiotensin II - pharmacology; Animal models; Animals; Aorta; Apoptosis; Biochemistry; Biomedical and Life Sciences; Biomedicine; Carbon dioxide; Cardiac function; Cardiomegaly - genetics; Cardiomegaly - metabolism; Cardiomegaly - pathology; Cardiomyocyte hypertrophy; Cardiomyocytes; cdc42 GTP-Binding Protein - antagonists & inhibitors; cdc42 GTP-Binding Protein - genetics; cdc42 GTP-Binding Protein - metabolism; Cdc42 protein; Cell Biology; Cell cycle; Cell division; Coronary vessels; Cycle protein; Cytoskeleton; Deletion; Fibrosis; Gene expression; Heart; Hypertrophy; Inflammation; Inhibitors; Kinases; Laboratory animals; Life Sciences; Male; MAP Kinase Kinase 3 - metabolism; MAP Kinase Kinase 6 - metabolism; MAP Kinase Signaling System; Membrane trafficking; Membranes; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Myocardium - metabolism; Myocardium - pathology; Myocytes; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Original; Original Article; p38 Mitogen-Activated Protein Kinases - metabolism; Penicillin; Polarization; Proteins; Rats; Signal Transduction; Thymus gland; Ventricular Remodeling; United States > US; Cardiomyocyte hypertrophy; Inflammation; Cardiac function; Apoptosis

Cell division cycle protein 42 (Cdc42) is a member of the Rho GTPase subfamily that serves as a signal mediating factor in cell cycle division, cytoskeleton arrangement, cell polarization, membrane trafficking and signal transduction. However, the role of Cdc42 in cardiac remodeling, including hyper...