Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue

• Published in: Journal of translational medicine Vol. 13; no. 1; p. 373
• Main Authors: García-Fuentes, Eduardo, Santiago-Fernández, Concepción, Gutiérrez-Repiso, Carolina, Mayas, María D., Oliva-Olivera, Wilfredo, Coín-Aragüez, Leticia, Alcaide, Juan, Ocaña-Wilhelmi, Luis, Vendrell, Joan, Tinahones, Francisco J., Garrido-Sánchez, Lourdes
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.11.2015; BioMed Central
• Subjects: Adipose tissues; Adult; Animals; Body fat; Female; Gene Expression Regulation; Genes; Genetic aspects; Genetic research; Humans; Hypoxia - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Insulin resistance; Intra-Abdominal Fat - metabolism; Lipogenesis - genetics; Male; Mice; Mice, Inbred C57BL; Middle Aged; Obesity; Obesity, Morbid - metabolism; RNA; RNA, Messenger - genetics

A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue. We studied HIF-1α mRNA and protein expression in fasting status in visceral adipose tissue (VAT) from non-obese an...