Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue

A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue. We studied HIF-1α mRNA and protein expression in fasting status in visceral adipose tissue (VAT) from non-obese an...

Full description

Saved in:
Bibliographic Details
Published inJournal of translational medicine Vol. 13; no. 1; p. 373
Main Authors García-Fuentes, Eduardo, Santiago-Fernández, Concepción, Gutiérrez-Repiso, Carolina, Mayas, María D., Oliva-Olivera, Wilfredo, Coín-Aragüez, Leticia, Alcaide, Juan, Ocaña-Wilhelmi, Luis, Vendrell, Joan, Tinahones, Francisco J., Garrido-Sánchez, Lourdes
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 30.11.2015
BioMed Central
Subjects
Adipose tissues
Adult
Animals
Body fat
Female
Gene Expression Regulation
Genes
Genetic aspects
Genetic research
Humans
Hypoxia - genetics
Hypoxia-Inducible Factor 1, alpha Subunit - genetics
Insulin resistance
Intra-Abdominal Fat - metabolism
Lipogenesis - genetics
Male
Mice
Mice, Inbred C57BL
Middle Aged
Obesity
Obesity, Morbid - metabolism
RNA
RNA, Messenger - genetics
Online AccessGet full text

Cover

Abstract A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue. We studied HIF-1α mRNA and protein expression in fasting status in visceral adipose tissue (VAT) from non-obese and morbidly obese subjects, and in VAT from wild-type and ob/ob C57BL6J mice in both fasting and feeding status. We also analyzed the effect of hypoxia on the VAT mRNA expression of genes involved in lipogenesis. HIF-1α was increased in VAT from morbidly obese subjects. In fasting status, C57BL6J ob/ob mice had a higher VAT HIF-1α mRNA expression than C57BL6J wild-type mice. In feeding status, VAT HIF-1α mRNA expression significantly increased in C57BL6J wild-type, but not in C57BL6J ob/ob mice. In humans, HIF-1α mRNA expression correlated positively with body mass index and insulin resistance. VAT HIF-1α mRNA expression correlated negatively with ACC1, PDHB and SIRT3 mRNA expression, and positively with PPAR-γ. VAT explants incubated in hypoxia showed reduced SIRT3 and increased PPAR-γ, SREBP-1c, ACLY, ACC1 and FASN mRNA expression. Morbidly obese subjects have a higher level of VAT HIF-1α. Postprandial status is associated with an increase in HIF-1α mRNA expression in C57BL6J wild-type mice. Hypoxia alters the mRNA expression of genes involved in de novo lipogenesis in human VAT.
AbstractList A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue. We studied HIF-1α mRNA and protein expression in fasting status in visceral adipose tissue (VAT) from non-obese and morbidly obese subjects, and in VAT from wild-type and ob/ob C57BL6J mice in both fasting and feeding status. We also analyzed the effect of hypoxia on the VAT mRNA expression of genes involved in lipogenesis. HIF-1α was increased in VAT from morbidly obese subjects. In fasting status, C57BL6J ob/ob mice had a higher VAT HIF-1α mRNA expression than C57BL6J wild-type mice. In feeding status, VAT HIF-1α mRNA expression significantly increased in C57BL6J wild-type, but not in C57BL6J ob/ob mice. In humans, HIF-1α mRNA expression correlated positively with body mass index and insulin resistance. VAT HIF-1α mRNA expression correlated negatively with ACC1, PDHB and SIRT3 mRNA expression, and positively with PPAR-γ. VAT explants incubated in hypoxia showed reduced SIRT3 and increased PPAR-γ, SREBP-1c, ACLY, ACC1 and FASN mRNA expression. Morbidly obese subjects have a higher level of VAT HIF-1α. Postprandial status is associated with an increase in HIF-1α mRNA expression in C57BL6J wild-type mice. Hypoxia alters the mRNA expression of genes involved in de novo lipogenesis in human VAT.
Background A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue. Methods We studied HIF-1α mRNA and protein expression in fasting status in visceral adipose tissue (VAT) from non-obese and morbidly obese subjects, and in VAT from wild-type and ob/ob C57BL6J mice in both fasting and feeding status. We also analyzed the effect of hypoxia on the VAT mRNA expression of genes involved in lipogenesis. Results HIF-1α was increased in VAT from morbidly obese subjects. In fasting status, C57BL6J ob/ob mice had a higher VAT HIF-1α mRNA expression than C57BL6J wild-type mice. In feeding status, VAT HIF-1α mRNA expression significantly increased in C57BL6J wild-type, but not in C57BL6J ob/ob mice. In humans, HIF-1α mRNA expression correlated positively with body mass index and insulin resistance. VAT HIF-1α mRNA expression correlated negatively with ACC1, PDHB and SIRT3 mRNA expression, and positively with PPAR-γ. VAT explants incubated in hypoxia showed reduced SIRT3 and increased PPAR-γ, SREBP-1c, ACLY, ACC1 and FASN mRNA expression. Conclusions Morbidly obese subjects have a higher level of VAT HIF-1α. Postprandial status is associated with an increase in HIF-1α mRNA expression in C57BL6J wild-type mice. Hypoxia alters the mRNA expression of genes involved in de novo lipogenesis in human VAT.
A key role for HIF-1[alpha] in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue. We studied HIF-1[alpha] mRNA and protein expression in fasting status in visceral adipose tissue (VAT) from non-obese and morbidly obese subjects, and in VAT from wild-type and ob/ob C57BL6J mice in both fasting and feeding status. We also analyzed the effect of hypoxia on the VAT mRNA expression of genes involved in lipogenesis. HIF-1[alpha] was increased in VAT from morbidly obese subjects. In fasting status, C57BL6J ob/ob mice had a higher VAT HIF-1[alpha] mRNA expression than C57BL6J wild-type mice. In feeding status, VAT HIF-1[alpha] mRNA expression significantly increased in C57BL6J wild-type, but not in C57BL6J ob/ob mice. In humans, HIF-1[alpha] mRNA expression correlated positively with body mass index and insulin resistance. VAT HIF-1[alpha] mRNA expression correlated negatively with ACC1, PDHB and SIRT3 mRNA expression, and positively with PPAR-[gamma]. VAT explants incubated in hypoxia showed reduced SIRT3 and increased PPAR-[gamma], SREBP-1c, ACLY, ACC1 and FASN mRNA expression. Morbidly obese subjects have a higher level of VAT HIF-1[alpha]. Postprandial status is associated with an increase in HIF-1[alpha] mRNA expression in C57BL6J wild-type mice. Hypoxia alters the mRNA expression of genes involved in de novo lipogenesis in human VAT.
Background A key role for HIF-1[alpha] in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue. Methods We studied HIF-1[alpha] mRNA and protein expression in fasting status in visceral adipose tissue (VAT) from non-obese and morbidly obese subjects, and in VAT from wild-type and ob/ob C57BL6J mice in both fasting and feeding status. We also analyzed the effect of hypoxia on the VAT mRNA expression of genes involved in lipogenesis. Results HIF-1[alpha] was increased in VAT from morbidly obese subjects. In fasting status, C57BL6J ob/ob mice had a higher VAT HIF-1[alpha] mRNA expression than C57BL6J wild-type mice. In feeding status, VAT HIF-1[alpha] mRNA expression significantly increased in C57BL6J wild-type, but not in C57BL6J ob/ob mice. In humans, HIF-1[alpha] mRNA expression correlated positively with body mass index and insulin resistance. VAT HIF-1[alpha] mRNA expression correlated negatively with ACC1, PDHB and SIRT3 mRNA expression, and positively with PPAR-[gamma]. VAT explants incubated in hypoxia showed reduced SIRT3 and increased PPAR-[gamma], SREBP-1c, ACLY, ACC1 and FASN mRNA expression. Conclusions Morbidly obese subjects have a higher level of VAT HIF-1[alpha]. Postprandial status is associated with an increase in HIF-1[alpha] mRNA expression in C57BL6J wild-type mice. Hypoxia alters the mRNA expression of genes involved in de novo lipogenesis in human VAT. Keywords: HIF-1[alpha], Hypoxia, Adipose tissue, Insulin resistance, Morbid obesity
A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue.BACKGROUNDA key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue.We studied HIF-1α mRNA and protein expression in fasting status in visceral adipose tissue (VAT) from non-obese and morbidly obese subjects, and in VAT from wild-type and ob/ob C57BL6J mice in both fasting and feeding status. We also analyzed the effect of hypoxia on the VAT mRNA expression of genes involved in lipogenesis.METHODSWe studied HIF-1α mRNA and protein expression in fasting status in visceral adipose tissue (VAT) from non-obese and morbidly obese subjects, and in VAT from wild-type and ob/ob C57BL6J mice in both fasting and feeding status. We also analyzed the effect of hypoxia on the VAT mRNA expression of genes involved in lipogenesis.HIF-1α was increased in VAT from morbidly obese subjects. In fasting status, C57BL6J ob/ob mice had a higher VAT HIF-1α mRNA expression than C57BL6J wild-type mice. In feeding status, VAT HIF-1α mRNA expression significantly increased in C57BL6J wild-type, but not in C57BL6J ob/ob mice. In humans, HIF-1α mRNA expression correlated positively with body mass index and insulin resistance. VAT HIF-1α mRNA expression correlated negatively with ACC1, PDHB and SIRT3 mRNA expression, and positively with PPAR-γ. VAT explants incubated in hypoxia showed reduced SIRT3 and increased PPAR-γ, SREBP-1c, ACLY, ACC1 and FASN mRNA expression.RESULTSHIF-1α was increased in VAT from morbidly obese subjects. In fasting status, C57BL6J ob/ob mice had a higher VAT HIF-1α mRNA expression than C57BL6J wild-type mice. In feeding status, VAT HIF-1α mRNA expression significantly increased in C57BL6J wild-type, but not in C57BL6J ob/ob mice. In humans, HIF-1α mRNA expression correlated positively with body mass index and insulin resistance. VAT HIF-1α mRNA expression correlated negatively with ACC1, PDHB and SIRT3 mRNA expression, and positively with PPAR-γ. VAT explants incubated in hypoxia showed reduced SIRT3 and increased PPAR-γ, SREBP-1c, ACLY, ACC1 and FASN mRNA expression.Morbidly obese subjects have a higher level of VAT HIF-1α. Postprandial status is associated with an increase in HIF-1α mRNA expression in C57BL6J wild-type mice. Hypoxia alters the mRNA expression of genes involved in de novo lipogenesis in human VAT.CONCLUSIONSMorbidly obese subjects have a higher level of VAT HIF-1α. Postprandial status is associated with an increase in HIF-1α mRNA expression in C57BL6J wild-type mice. Hypoxia alters the mRNA expression of genes involved in de novo lipogenesis in human VAT.
ArticleNumber 373
Audience Academic
Author Vendrell, Joan
Mayas, María D.
Garrido-Sánchez, Lourdes
Gutiérrez-Repiso, Carolina
Santiago-Fernández, Concepción
Oliva-Olivera, Wilfredo
García-Fuentes, Eduardo
Coín-Aragüez, Leticia
Alcaide, Juan
Ocaña-Wilhelmi, Luis
Tinahones, Francisco J.
Author_xml – sequence: 1
  givenname: Eduardo
  surname: García-Fuentes
  fullname: García-Fuentes, Eduardo
– sequence: 2
  givenname: Concepción
  surname: Santiago-Fernández
  fullname: Santiago-Fernández, Concepción
– sequence: 3
  givenname: Carolina
  surname: Gutiérrez-Repiso
  fullname: Gutiérrez-Repiso, Carolina
– sequence: 4
  givenname: María D.
  surname: Mayas
  fullname: Mayas, María D.
– sequence: 5
  givenname: Wilfredo
  surname: Oliva-Olivera
  fullname: Oliva-Olivera, Wilfredo
– sequence: 6
  givenname: Leticia
  surname: Coín-Aragüez
  fullname: Coín-Aragüez, Leticia
– sequence: 7
  givenname: Juan
  surname: Alcaide
  fullname: Alcaide, Juan
– sequence: 8
  givenname: Luis
  surname: Ocaña-Wilhelmi
  fullname: Ocaña-Wilhelmi, Luis
– sequence: 9
  givenname: Joan
  surname: Vendrell
  fullname: Vendrell, Joan
– sequence: 10
  givenname: Francisco J.
  surname: Tinahones
  fullname: Tinahones, Francisco J.
– sequence: 11
  givenname: Lourdes
  surname: Garrido-Sánchez
  fullname: Garrido-Sánchez, Lourdes
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26619907$$D View this record in MEDLINE/PubMed
BookMark eNp9kk1v1DAQhi1URD_gB3BBlrhwSfFX7OSCVFXQIlXiAmfL60y2U3ntECfb9t_XYdvSVgj5YHvmeV97NHNI9mKKQMh7zo45b_TnzEWrTcV4XTEjRVW_IgdcmbaqG6P3npz3yWHOV4wJVav2DdkXWvO2ZeaA4PntkG7QUczU5Zw8ugk6eo3TJXU0pGsYKdwMI-SMKdLU0zVEyBTjNoVtITHSgEP6E8UlTreYPYwuUNeVRAY6Yc4zvCWvexcyvLvfj8ivb19_np5XFz_Ovp-eXFRetWqqZM8asdI96EYYxzn3TogGfKe8EUaBX0koN9H0UksQhrOSWfnO9U7Jwsoj8mXnO8yrDXQe4lQ-Y4cRN268tcmhfZ6JeGnXaWuV1tIIWQw-3RuM6fcMebKbpaIQXIQ0Z8uNbBpeC9kW9OML9CrNYyzlFcq0htXc6L_U2gWwGPtU3vWLqT1RumWNlGrxOv4HVVYHG_Sl8T2W-DPBh6eFPlb40NwC8B3gx5TzCP0jwpldBsjuBsiWAbLLANm6aMwLjcfJTaX35TcY_qO8A8oMy0s
CitedBy_id crossref_primary_10_1016_j_diabet_2016_12_002
crossref_primary_10_1016_j_exger_2019_03_011
crossref_primary_10_3390_cells11152282
crossref_primary_10_3390_metabo14050249
crossref_primary_10_1186_s12967_019_1842_2
crossref_primary_10_1186_s13046_023_02607_2
crossref_primary_10_1039_C6AY01244B
crossref_primary_10_3389_fendo_2018_00748
crossref_primary_10_1016_j_jep_2024_118465
crossref_primary_10_1210_clinem_dgaa580
crossref_primary_10_3389_fnins_2018_00799
crossref_primary_10_1038_nrendo_2016_22
crossref_primary_10_1186_s12967_016_0965_y
crossref_primary_10_1002_jdn_10321
crossref_primary_10_4103_ijem_ijem_400_23
crossref_primary_10_1016_j_acra_2024_07_044
crossref_primary_10_3390_ani11113238
crossref_primary_10_1007_s11547_020_01310_y
crossref_primary_10_1289_EHP481
crossref_primary_10_1038_ijo_2017_145
crossref_primary_10_1186_s12915_021_01192_0
crossref_primary_10_3390_biology10030194
crossref_primary_10_3390_biomedicines9111715
crossref_primary_10_1186_s13046_023_02842_7
crossref_primary_10_3390_cancers17030372
crossref_primary_10_1002_oby_22363
crossref_primary_10_3390_cimb46040203
crossref_primary_10_14341_omet13096
crossref_primary_10_1016_j_obmed_2022_100432
crossref_primary_10_3390_cancers11121971
Cites_doi 10.1016/j.cmet.2006.02.002
10.1042/BJ20071052
10.1042/BJ20061722
10.1074/jbc.275.17.12497
10.1038/sj.ijo.0803744
10.1634/stemcells.2004-0038
10.1038/ijo.2013.200
10.1002/ijc.24918
10.1002/(SICI)1096-9136(1998120)15:4+3.3.CO;2-Z
10.1007/s00424-007-0301-8
10.1016/j.tcm.2014.03.004
10.1073/pnas.1534923100
10.1017/S0007114508971282
10.2337/db08-0457
10.1074/jbc.270.22.12953
10.2337/db06-0911
10.1128/MCB.00192-09
10.1002/jcb.24247
10.4161/cbt.11.8.15274
10.1016/0003-2697(66)90172-2
10.1007/s11695-010-0194-z
10.1016/S0955-0674(00)00194-0
10.2337/db12-1032
10.1371/journal.pone.0050545
10.2337/diabetes.51.8.2467
10.1101/gad.180406.111
10.1158/0008-5472.CAN-07-2489
10.1371/journal.pone.0033264
10.1210/jc.2009-2377
10.2119/molmed.2010.00078
10.1371/journal.pone.0031280
10.1152/ajpendo.00626.2010
10.1371/journal.pone.0063937
10.3346/jkms.2002.17.5.581
10.1016/j.soard.2013.12.011
10.21769/BioProtoc.256
10.1073/pnas.0603968103
10.1007/s11745-004-1333-0
10.1016/j.ddmec.2013.04.001
10.1016/j.jhep.2011.04.022
10.1056/NEJMra0910283
10.1507/endocrj.K09E-298
10.1042/cs0910679
10.1101/gad.14.16.1983
10.1007/BF00963805
10.1002/9783527659227
ContentType Journal Article
Copyright COPYRIGHT 2015 BioMed Central Ltd.
Copyright BioMed Central 2015
García-Fuentes et al. 2015
Copyright_xml – notice: COPYRIGHT 2015 BioMed Central Ltd.
– notice: Copyright BioMed Central 2015
– notice: García-Fuentes et al. 2015
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7T5
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
H94
K9.
M0S
M1P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOI 10.1186/s12967-015-0732-5
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Immunology Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni)
Medical Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Immunology Abstracts
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE
Publicly Available Content Database


MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1479-5876
ExternalDocumentID PMC4663723
4016374141
A469083349
26619907
10_1186_s12967_015_0732_5
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
0R~
29L
2WC
4.4
53G
5VS
6PF
7X7
88E
8FI
8FJ
AAFWJ
AAJSJ
AASML
AAWTL
AAYXX
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AFRAH
AHBYD
AHMBA
AHSBF
AHYZX
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C6C
CCPQU
CITATION
CS3
DIK
DU5
E3Z
EBD
EBLON
EBS
EJD
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
H13
HMCUK
HYE
IAO
IHR
INH
INR
IPNFZ
ITC
KQ8
M1P
M48
M~E
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RBZ
RIG
RNS
ROL
RPM
RSV
SBL
SOJ
TR2
TUS
UKHRP
WOQ
WOW
XSB
~8M
CGR
CUY
CVF
ECM
EIF
NPM
PMFND
3V.
7T5
7XB
8FK
AZQEC
DWQXO
H94
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c494t-3f082b6fe6827a111ca228ecd4c7274ecb3eecd28f363e2710d4cbcdafa43ca23
IEDL.DBID M48
ISSN 1479-5876
IngestDate Thu Aug 21 18:20:10 EDT 2025
Fri Jul 11 04:31:19 EDT 2025
Fri Jul 25 07:41:25 EDT 2025
Tue Jun 17 22:05:42 EDT 2025
Tue Jun 10 21:04:44 EDT 2025
Thu Apr 03 06:59:19 EDT 2025
Thu Apr 24 22:53:33 EDT 2025
Tue Jul 01 03:51:07 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c494t-3f082b6fe6827a111ca228ecd4c7274ecb3eecd28f363e2710d4cbcdafa43ca23
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1186/s12967-015-0732-5
PMID 26619907
PQID 1779705176
PQPubID 43076
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4663723
proquest_miscellaneous_1738815239
proquest_journals_1779705176
gale_infotracmisc_A469083349
gale_infotracacademiconefile_A469083349
pubmed_primary_26619907
crossref_primary_10_1186_s12967_015_0732_5
crossref_citationtrail_10_1186_s12967_015_0732_5
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2015-11-30
PublicationDateYYYYMMDD 2015-11-30
PublicationDate_xml – month: 11
  year: 2015
  text: 2015-11-30
  day: 30
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Journal of translational medicine
PublicationTitleAlternate J Transl Med
PublicationYear 2015
Publisher BioMed Central Ltd
BioMed Central
Publisher_xml – name: BioMed Central Ltd
– name: BioMed Central
References GL Semenza (732_CR2) 2001; 13
JM Lehmann (732_CR37) 1995; 270
J Aron-Wisnewsky (732_CR34) 2012; 56
S García-Serrano (732_CR25) 2011; 17
L Hodson (732_CR29) 2013; 62
SY Jung (732_CR38) 2012; 113
LK Summers (732_CR11) 1996; 91
SA Newsom (732_CR23) 2013; 10
ME Beckner (732_CR18) 2010; 126
N Halberg (732_CR36) 2009; 29
HJ Harwood Jr (732_CR21) 2004; 5
JW Kim (732_CR20) 2006; 3
P Trayhurn (732_CR7) 2008; 100
Q He (732_CR8) 2011; 300
J Jiang (732_CR48) 2011; 11
S Castaño-Cerezo (732_CR32) 2012; 2
B Wang (732_CR9) 2007; 455
LF Zhao (732_CR43) 2010; 57
L Garrido-Sánchez (732_CR6) 2012; 7
T Fink (732_CR16) 2004; 22
D Villar (732_CR3) 2007; 408
ME Rausch (732_CR5) 2008; 32
L Garrido-Sánchez (732_CR27) 2012; 7
B Schwer (732_CR19) 2006; 103
R Sato (732_CR42) 2000; 275
PJ Lefèbvre (732_CR30) 1998; 15
MT Nakamura (732_CR39) 2004; 39
EM Sol (732_CR41) 2012; 7
J Krishnan (732_CR17) 2012; 26
N Hosogai (732_CR4) 2007; 56
JD Horton (732_CR44) 2003; 100
KN Frayn (732_CR10) 2014; 38
F Yuan (732_CR12) 2015; 7
YS Chun (732_CR46) 2002; 17
HK Eltzschig (732_CR47) 2011; 364
GL Semenza (732_CR1) 2000; 14
F Karpe (732_CR13) 2002; 51
L Garrido-Sanchez (732_CR26) 2013; 8
T Ichiki (732_CR14) 2014; 24
C Regazzetti (732_CR15) 2009; 58
H Moellering (732_CR33) 1966; 17
E Furuta (732_CR22) 2008; 68
U Rafalowska (732_CR45) 1979; 4
L Garrido-Sánchez (732_CR28) 2014; 10
M Teran-Garcia (732_CR40) 2007; 402
FJ Tinahones (732_CR24) 2010; 20
H Bisswanger (732_CR31) 2011
M Pasarica (732_CR35) 2010; 95
24774124 - Trends Cardiovasc Med. 2014 Jul;24(5):197-201
18397542 - Br J Nutr. 2008 Aug;100(2):227-35
12378005 - J Korean Med Sci. 2002 Oct;17(5):581-8
23236377 - PLoS One. 2012;7(12):e50545
7768881 - J Biol Chem. 1995 Jun 2;270(22):12953-6
14512514 - Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12027-32
17895881 - Int J Obes (Lond). 2008 Mar;32(3):451-63
20466783 - J Clin Endocrinol Metab. 2010 Aug;95(8):4052-5
21703181 - J Hepatol. 2012 Jan;56(1):225-33
460527 - Neurochem Res. 1979 Jun;4(3):355-64
26045898 - Am J Transl Res. 2015 Mar 15;7(3):598-606
22786746 - J Cell Biochem. 2012 Dec;113(12):3730-9
20139635 - Endocr J. 2010;57(4):317-24
10950862 - Genes Dev. 2000 Aug 15;14(16):1983-91
22442679 - PLoS One. 2012;7(3):e33264
16788062 - Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10224-9
16517405 - Cell Metab. 2006 Mar;3(3):177-85
22384010 - PLoS One. 2012;7(2):e31280
23700440 - PLoS One. 2013;8(5):e63937
9868996 - Diabet Med. 1998;15 Suppl 4:S63-8
17313375 - Biochem J. 2007 Mar 15;402(3):591-600
15083594 - Curr Opin Investig Drugs. 2004 Mar;5(3):283-9
17725546 - Biochem J. 2007 Dec 1;408(2):231-40
20512427 - Obes Surg. 2010 Nov;20(11):1559-67
17609976 - Pflugers Arch. 2007 Dec;455(3):479-92
15726822 - Lipids. 2004 Nov;39(11):1077-83
19546236 - Mol Cell Biol. 2009 Aug;29(16):4467-83
22302938 - Genes Dev. 2012 Feb 1;26(3):259-70
21343542 - Am J Physiol Endocrinol Metab. 2011 May;300(5):E877-85
11248550 - Curr Opin Cell Biol. 2001 Apr;13(2):167-71
23997790 - Drug Discov Today Dis Mech. 2013 Jun 1;10(1-2):e35-e40
12145159 - Diabetes. 2002 Aug;51(8):2467-73
23274888 - Diabetes. 2013 May;62(5):1417-25
21323543 - N Engl J Med. 2011 Feb 17;364(7):656-65
19795461 - Int J Cancer. 2010 May 15;126(10):2282-95
15579652 - Stem Cells. 2004;22(7):1346-55
24166067 - Int J Obes (Lond). 2014 Aug;38(8):1019-26
5965976 - Anal Biochem. 1966 Dec;17(3):369-76
10777536 - J Biol Chem. 2000 Apr 28;275(17):12497-502
24708911 - Surg Obes Relat Dis. 2014 Jul-Aug;10(4):691-6
18984735 - Diabetes. 2009 Jan;58(1):95-103
21389772 - Cancer Biol Ther. 2011 Apr 15;11(8):714-23
18281474 - Cancer Res. 2008 Feb 15;68(4):1003-11
8976802 - Clin Sci (Lond). 1996 Dec;91(6):679-83
17395738 - Diabetes. 2007 Apr;56(4):901-11
21060977 - Mol Med. 2011 Mar-Apr;17(3-4):273-80
References_xml – volume: 3
  start-page: 177
  year: 2006
  ident: 732_CR20
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2006.02.002
– volume: 408
  start-page: 231
  year: 2007
  ident: 732_CR3
  publication-title: Biochem J
  doi: 10.1042/BJ20071052
– volume: 402
  start-page: 591
  year: 2007
  ident: 732_CR40
  publication-title: Biochem J
  doi: 10.1042/BJ20061722
– volume: 275
  start-page: 12497
  year: 2000
  ident: 732_CR42
  publication-title: J Biol Chem
  doi: 10.1074/jbc.275.17.12497
– volume: 5
  start-page: 283
  year: 2004
  ident: 732_CR21
  publication-title: Curr Opin Investig Drugs
– volume: 32
  start-page: 451
  year: 2008
  ident: 732_CR5
  publication-title: Int J Obes (Lond).
  doi: 10.1038/sj.ijo.0803744
– volume: 22
  start-page: 1346
  year: 2004
  ident: 732_CR16
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2004-0038
– volume: 38
  start-page: 1019
  year: 2014
  ident: 732_CR10
  publication-title: Int J Obes (Lond).
  doi: 10.1038/ijo.2013.200
– volume: 126
  start-page: 2282
  year: 2010
  ident: 732_CR18
  publication-title: Int J Cancer
  doi: 10.1002/ijc.24918
– volume: 15
  start-page: S63
  issue: Suppl 4
  year: 1998
  ident: 732_CR30
  publication-title: Diabet Med
  doi: 10.1002/(SICI)1096-9136(1998120)15:4+3.3.CO;2-Z
– volume: 455
  start-page: 479
  year: 2007
  ident: 732_CR9
  publication-title: Pflugers Arch
  doi: 10.1007/s00424-007-0301-8
– volume: 24
  start-page: 197
  year: 2014
  ident: 732_CR14
  publication-title: Trends Cardiovasc Med
  doi: 10.1016/j.tcm.2014.03.004
– volume: 100
  start-page: 12027
  year: 2003
  ident: 732_CR44
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.1534923100
– volume: 100
  start-page: 227
  year: 2008
  ident: 732_CR7
  publication-title: Br J Nutr
  doi: 10.1017/S0007114508971282
– volume: 7
  start-page: 598
  year: 2015
  ident: 732_CR12
  publication-title: Am J Transl Res.
– volume: 58
  start-page: 95
  year: 2009
  ident: 732_CR15
  publication-title: Diabetes
  doi: 10.2337/db08-0457
– volume: 270
  start-page: 12953
  year: 1995
  ident: 732_CR37
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.22.12953
– volume: 56
  start-page: 901
  year: 2007
  ident: 732_CR4
  publication-title: Diabetes
  doi: 10.2337/db06-0911
– volume: 29
  start-page: 4467
  year: 2009
  ident: 732_CR36
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00192-09
– volume: 113
  start-page: 3730
  year: 2012
  ident: 732_CR38
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.24247
– volume: 11
  start-page: 714
  year: 2011
  ident: 732_CR48
  publication-title: Cancer Biol Ther
  doi: 10.4161/cbt.11.8.15274
– volume: 17
  start-page: 369
  year: 1966
  ident: 732_CR33
  publication-title: Anal Biochem
  doi: 10.1016/0003-2697(66)90172-2
– volume: 20
  start-page: 1559
  year: 2010
  ident: 732_CR24
  publication-title: Obes Surg
  doi: 10.1007/s11695-010-0194-z
– volume: 13
  start-page: 167
  year: 2001
  ident: 732_CR2
  publication-title: Curr Opin Cell Biol
  doi: 10.1016/S0955-0674(00)00194-0
– volume: 62
  start-page: 1417
  year: 2013
  ident: 732_CR29
  publication-title: Diabetes
  doi: 10.2337/db12-1032
– volume: 7
  start-page: e50545
  year: 2012
  ident: 732_CR41
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0050545
– volume: 51
  start-page: 2467
  year: 2002
  ident: 732_CR13
  publication-title: Diabetes
  doi: 10.2337/diabetes.51.8.2467
– volume: 26
  start-page: 259
  year: 2012
  ident: 732_CR17
  publication-title: Genes Dev
  doi: 10.1101/gad.180406.111
– volume: 68
  start-page: 1003
  year: 2008
  ident: 732_CR22
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-07-2489
– volume: 7
  start-page: e33264
  year: 2012
  ident: 732_CR27
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0033264
– volume: 95
  start-page: 4052
  year: 2010
  ident: 732_CR35
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2009-2377
– volume: 17
  start-page: 273
  year: 2011
  ident: 732_CR25
  publication-title: Mol Med
  doi: 10.2119/molmed.2010.00078
– volume: 7
  start-page: e31280
  year: 2012
  ident: 732_CR6
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0031280
– volume: 300
  start-page: E877
  year: 2011
  ident: 732_CR8
  publication-title: Am J Physiol Endocrinol Metab.
  doi: 10.1152/ajpendo.00626.2010
– volume: 8
  start-page: e63937
  year: 2013
  ident: 732_CR26
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0063937
– volume: 17
  start-page: 581
  year: 2002
  ident: 732_CR46
  publication-title: J Korean Med Sci
  doi: 10.3346/jkms.2002.17.5.581
– volume: 10
  start-page: 691
  year: 2014
  ident: 732_CR28
  publication-title: Surg Obes Relat Dis.
  doi: 10.1016/j.soard.2013.12.011
– volume: 2
  start-page: e256
  year: 2012
  ident: 732_CR32
  publication-title: Bio-protocol.
  doi: 10.21769/BioProtoc.256
– volume: 103
  start-page: 10224
  year: 2006
  ident: 732_CR19
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0603968103
– volume: 39
  start-page: 1077
  year: 2004
  ident: 732_CR39
  publication-title: Lipids
  doi: 10.1007/s11745-004-1333-0
– volume: 10
  start-page: e35
  year: 2013
  ident: 732_CR23
  publication-title: Drug Discov Today Dis Mech.
  doi: 10.1016/j.ddmec.2013.04.001
– volume: 56
  start-page: 225
  year: 2012
  ident: 732_CR34
  publication-title: J Hepatol
  doi: 10.1016/j.jhep.2011.04.022
– volume: 364
  start-page: 656
  year: 2011
  ident: 732_CR47
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra0910283
– volume: 57
  start-page: 317
  year: 2010
  ident: 732_CR43
  publication-title: Endocr J
  doi: 10.1507/endocrj.K09E-298
– volume: 91
  start-page: 679
  year: 1996
  ident: 732_CR11
  publication-title: Clin Sci (Lond).
  doi: 10.1042/cs0910679
– volume: 14
  start-page: 1983
  year: 2000
  ident: 732_CR1
  publication-title: Genes Dev
  doi: 10.1101/gad.14.16.1983
– volume: 4
  start-page: 355
  year: 1979
  ident: 732_CR45
  publication-title: Neurochem Res
  doi: 10.1007/BF00963805
– start-page: 93
  volume-title: Practical Enzymology
  year: 2011
  ident: 732_CR31
  doi: 10.1002/9783527659227
– reference: 17395738 - Diabetes. 2007 Apr;56(4):901-11
– reference: 18281474 - Cancer Res. 2008 Feb 15;68(4):1003-11
– reference: 16788062 - Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10224-9
– reference: 23274888 - Diabetes. 2013 May;62(5):1417-25
– reference: 18397542 - Br J Nutr. 2008 Aug;100(2):227-35
– reference: 9868996 - Diabet Med. 1998;15 Suppl 4:S63-8
– reference: 7768881 - J Biol Chem. 1995 Jun 2;270(22):12953-6
– reference: 24774124 - Trends Cardiovasc Med. 2014 Jul;24(5):197-201
– reference: 16517405 - Cell Metab. 2006 Mar;3(3):177-85
– reference: 23997790 - Drug Discov Today Dis Mech. 2013 Jun 1;10(1-2):e35-e40
– reference: 19795461 - Int J Cancer. 2010 May 15;126(10):2282-95
– reference: 19546236 - Mol Cell Biol. 2009 Aug;29(16):4467-83
– reference: 21343542 - Am J Physiol Endocrinol Metab. 2011 May;300(5):E877-85
– reference: 14512514 - Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12027-32
– reference: 26045898 - Am J Transl Res. 2015 Mar 15;7(3):598-606
– reference: 15083594 - Curr Opin Investig Drugs. 2004 Mar;5(3):283-9
– reference: 8976802 - Clin Sci (Lond). 1996 Dec;91(6):679-83
– reference: 17609976 - Pflugers Arch. 2007 Dec;455(3):479-92
– reference: 10950862 - Genes Dev. 2000 Aug 15;14(16):1983-91
– reference: 24708911 - Surg Obes Relat Dis. 2014 Jul-Aug;10(4):691-6
– reference: 22302938 - Genes Dev. 2012 Feb 1;26(3):259-70
– reference: 12378005 - J Korean Med Sci. 2002 Oct;17(5):581-8
– reference: 17895881 - Int J Obes (Lond). 2008 Mar;32(3):451-63
– reference: 22384010 - PLoS One. 2012;7(2):e31280
– reference: 21323543 - N Engl J Med. 2011 Feb 17;364(7):656-65
– reference: 17313375 - Biochem J. 2007 Mar 15;402(3):591-600
– reference: 10777536 - J Biol Chem. 2000 Apr 28;275(17):12497-502
– reference: 460527 - Neurochem Res. 1979 Jun;4(3):355-64
– reference: 18984735 - Diabetes. 2009 Jan;58(1):95-103
– reference: 23700440 - PLoS One. 2013;8(5):e63937
– reference: 20512427 - Obes Surg. 2010 Nov;20(11):1559-67
– reference: 20466783 - J Clin Endocrinol Metab. 2010 Aug;95(8):4052-5
– reference: 21389772 - Cancer Biol Ther. 2011 Apr 15;11(8):714-23
– reference: 15579652 - Stem Cells. 2004;22(7):1346-55
– reference: 23236377 - PLoS One. 2012;7(12):e50545
– reference: 21703181 - J Hepatol. 2012 Jan;56(1):225-33
– reference: 24166067 - Int J Obes (Lond). 2014 Aug;38(8):1019-26
– reference: 21060977 - Mol Med. 2011 Mar-Apr;17(3-4):273-80
– reference: 11248550 - Curr Opin Cell Biol. 2001 Apr;13(2):167-71
– reference: 5965976 - Anal Biochem. 1966 Dec;17(3):369-76
– reference: 15726822 - Lipids. 2004 Nov;39(11):1077-83
– reference: 22786746 - J Cell Biochem. 2012 Dec;113(12):3730-9
– reference: 17725546 - Biochem J. 2007 Dec 1;408(2):231-40
– reference: 12145159 - Diabetes. 2002 Aug;51(8):2467-73
– reference: 20139635 - Endocr J. 2010;57(4):317-24
– reference: 22442679 - PLoS One. 2012;7(3):e33264
SSID ssj0024549
Score 2.2718325
Snippet A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo...
Background A key role for HIF-1[alpha] in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and...
A key role for HIF-1[alpha] in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo...
Background A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo...
SourceID pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 373
SubjectTerms Adipose tissues
Adult
Animals
Body fat
Female
Gene Expression Regulation
Genes
Genetic aspects
Genetic research
Humans
Hypoxia - genetics
Hypoxia-Inducible Factor 1, alpha Subunit - genetics
Insulin resistance
Intra-Abdominal Fat - metabolism
Lipogenesis - genetics
Male
Mice
Mice, Inbred C57BL
Middle Aged
Obesity
Obesity, Morbid - metabolism
RNA
RNA, Messenger - genetics
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR1daxQxMGgF8UX8dmuVCIIghLpJNsk-SRHLIeiThXsLSTbRwLF7da-l_vvO7OWuXR_6mMxkCZnJfGV2hpAPQvlWadmyunYNk7WPzEmZmPLgxiVwnGGA2RY_1eJMfl82yxJwG0ta5U4mToK6GwLGyI9rrVuNBaXUl_U5w65R-LpaWmjcJw-wdBmmdOnljcMlwfkpL5m1Uccj6DaFiZYNA8YGH2ymi_6XyLdU0jxd8pb-OX1CHhfDkZ5sKf2U3Iv9M_LwR3kaf07y4t96uMqO5pG6cuaxoxhnpY6usBkajVcl7bWnQ6K_UczR3IOAugTM3NNVXg_TbMZ5epnHgCEr6joAjJFuJiq9IGen3359XbDSR4EF2coNEwn0vFcpKsO1A-EWHOcmhk4GsF5kDF5EGHGThBKRg80BEB86l5wUgCtekoN-6ONrQhvpuVFGqeSd1DH55LH_JJgxseVOxop83p2oDaXIOPa6WNnJ2TDKbolggQgWiWCbinzaL1lvK2zchfwRyWTx9sF3gys_EcDusI6VPUFv3wgh24oczTDh1oQ5eEdoW27taG94rCLv92BciZlofRwuEEcYA0aPgE-82vLFftto7IB21xXRM47ZI2At7zmkz3-mmt4SLD_NxeHd23pDHnFk36n05BE52Py9iG_BKNr4dxPnXwOAnQ00
  priority: 102
  providerName: ProQuest
Title Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue
URI https://www.ncbi.nlm.nih.gov/pubmed/26619907
https://www.proquest.com/docview/1779705176
https://www.proquest.com/docview/1738815239
https://pubmed.ncbi.nlm.nih.gov/PMC4663723
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3di9QwEB_uA8QX8dvquUQQBKHqNmmSPojcyR2LcIccLiy-hCSbaGFp1-vesfffO9Nt16ucviy0Mwml853O_gbgNZeukEoU6Xhs81SMXUitEDGVDsu4iIUzXlC3xZmcTMWXWT7bgX68VfcCm1tLO5onNb1YvFv_uv6EBv-xNXgt3zcYsyQ1UOYpKizWVruwj4FJkZ2eCv0Heg9roe7D5q3LCBgYwxX6ZzWIUn_76hvBathIeSMyndyHe11KyQ43OvAAdkL1EO6cdh_NH0E5uV7W69KysmG2k0aYMzqBZZYtaEwaC-uuIbZidWQ_yAGyskLXdYWcZcUW5bJu75Z0n12VjafDLGbnSGgCW7XyewzTk-NvnydpN2Eh9aIQq5RHzACcjEHqTFl0e95mmQ5-LjzmNSJ4xwNeZTpyyUOG2QhSnJ_baAVHXv4E9qq6Cs-A5cJlWmopo7NCheiio8mUmOCEIrMiJPChf6PGd_DjNAVjYdoyREuzkYdBeRiSh8kTeLtdstxgb_yP-Q2JyZCm4L7edn8vwKcjhCtzSOcAmnNRJHAw4ER78kNyL2jTq6MZK1UogjOTCbzakmkl9ahVob4kHq41pkMct3i60YvtY_d6lYAaaMyWgVC-h5Sq_NmifQvMCVXGn_9zzxdwNyMlbvEoD2BvdXEZXmKmtHIj2FUzNYL9o-Ozr-ej9rxh1NoE_p4fff8NNUkUhQ
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtQwcFS2EvSCeBMoYCQQElJUYnud5IBQgVZb2q4QaqXeXNtxaKRVspBtaX-Kb2Qmj23Dobce7ZlYludtT2YA3ghlUxXLNIwiMw5lZH1opMxDZTGMyzFwxgFlW0zV5FB-OxofrcDf_l8YSqvsdWKjqLPK0R35RhTHaUwFpdSn-a-QukbR62rfQqNli11_8QdDtvrjzlek71vOt7cOvkzCrqtA6GQqF6HI0epZlXuV8NigqDvDeeJdJh3acumdFR5HPMmFEp6jBUaIdZnJjRSIK3DdW7AqBYYyI1j9vDX9_uOyuh-GW93baZSojRqtqaLUznGIooRR38D6_W8DrhjBYYLmFYu3fQ_udq4q22x56z6s-PIB3N7vHuMfQjG5mFfnhWFFzUxHZZ8xutllhs2o_Rrz512ibcmqnP0kxcqKElXiGWIWJZsV86qZLWienRW1o0syZjIE1J4tGr54BIc3csaPYVRWpX8KbCwtT1SiVG6NjH1uc0sdL9Fx8ik30gfwoT9R7bqy5tRdY6ab8CZRuiWCRiJoIoIeB_B--cm8relxHfI7IpMmecd1nel-W8DdUeUsvUn3C4kQMg1gfYCJcuqG4J7QutMTtb7k6gBeL8H0JeW-lb46JRyRJOhmCVziScsXy22Te4X-RBxAPOCYJQJVDx9CyuKkqSIu0deMuXh2_bZewZ3Jwf6e3tuZ7j6HNU6s3BS-XIfR4vepf4Eu2cK-7OSAwfFNi94_KEJNTQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hypoxia+is+associated+with+a+lower+expression+of+genes+involved+in+lipogenesis+in+visceral+adipose+tissue&rft.jtitle=Journal+of+translational+medicine&rft.au=Garc%C3%ADa-Fuentes%2C+Eduardo&rft.au=Santiago-Fern%C3%A1ndez%2C+Concepci%C3%B3n&rft.au=Guti%C3%A9rrez-Repiso%2C+Carolina&rft.au=Mayas%2C+Mar%C3%ADa+D&rft.date=2015-11-30&rft.eissn=1479-5876&rft.volume=13&rft.spage=373&rft_id=info:doi/10.1186%2Fs12967-015-0732-5&rft_id=info%3Apmid%2F26619907&rft.externalDocID=26619907
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1479-5876&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1479-5876&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1479-5876&client=summon