Dexamethasone, celecoxib, and simvastatin-induced 5-fluorouracil resistance in cancer cells: a possible role of lipid droplet accumulation

• Published in: Discover. Oncology Vol. 16; no. 1; pp. 1331 - 11
• Main Authors: Sabbah, Duaa S., Ikhmais, Balqis A., Abdallah, Qasem M., Phillips, Roger M., Qinna, Nidal A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 14.07.2025; Springer Nature B.V; Springer
• Subjects: 5-fluorouracil; Acids; Cancer Research; Cancer therapies; Cells; Chemoresistance; Drug-drug interactions; Drugs; Internal Medicine; Lipid droplets; Lipids; Medicine; Medicine & Public Health; Metabolism; Molecular Medicine; Non-anticancer drugs; Oncology; Radiotherapy; Reproducibility; Surgical Oncology; United Kingdom > UK; United States > US; 5-fluorouracil; Drug-drug interactions; Lipid droplets; Non-anticancer drugs; Chemoresistance

Aim This study investigates the impact of dexamethasone (DEX), celecoxib (CXB), and simvastatin (SMV) on 5-fluorouracil (5-FU) resistance in cancer cells and their role in increasing lipid droplet (LD) accumulation. The study aims to assess how these non-anticancer drugs may influence the efficacy o...