JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α–mediated glucose metabolism

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 1; pp. 279 - 284
• Main Authors: Wang, Hung-Jung, Hsieh, Ya-Ju, Cheng, Wen-Chi, Lin, Chun-Pu, Lin, Yu-shan, Yang, So-Fang, Chen, Chung-Ching, Izumiya, Yoshihiro, Yu, Jau-Song, Kung, Hsing-Jien, Wang, Wen-Ching
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 07.01.2014; National Acad Sciences
• Subjects: Active Transport, Cell Nucleus; Allosteric regulation; Allosteric Site; Biological Sciences; Breast Neoplasms - metabolism; Carrier Proteins - metabolism; Cell growth; Cell Line, Tumor; Cell lines; Cell nucleus; Cell Nucleus - metabolism; Cell Proliferation; Cellular metabolism; embryogenesis; Female; Gene expression regulation; Gene Expression Regulation, Neoplastic; genes; glucose; Glucose - metabolism; Glycolysis; HEK293 Cells; HeLa Cells; Histone Demethylases - metabolism; Humans; Hypoxia; hypoxia-inducible factor 1; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Isoenzymes - metabolism; isozymes; L-Lactate Dehydrogenase - metabolism; lactate dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid - metabolism; loci; MCF-7 Cells; Membrane Proteins - metabolism; metabolism; muscles; neoplasm cells; neoplasms; Neoplasms - metabolism; Protein Binding; Protein Structure, Quaternary; pyruvate kinase; secretion; Thyroid Hormone-Binding Proteins; Thyroid Hormones - metabolism; Transactivation; Transcriptional Activation; cancer metabolism; breast cancer; aerobic glycolysis; Warburg effect

JMJD5, a Jumonji C domain-containing dioxygenase, is important for embryonic development and cancer growth. Here, we show that JMJD5 is up-regulated by hypoxia and is crucial for hypoxia-induced cell proliferation. JMJD5 interacts directly with pyruvate kinase muscle isozyme (PKM)2 to modulate metab...