JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α–mediated glucose metabolism - Wang, Hung-Jung; Hsieh, Ya-Ju; Cheng, Wen-Chi; Lin, Chun-Pu; Lin, Yu-shan; Yang, So-Fang; Chen, Chung-Ching; Izumiya, Yoshihiro; Yu, Jau-Song; Kung, Hsing-Jien; Wang, Wen-Ching (Proceedings of the National Academy of Sciences - PNAS, 2014)
Keywords: Active Transport, Cell Nucleus; Allosteric regulation; Allosteric Site; Biological Sciences; Breast Neoplasms - metabolism; Carrier Proteins - metabolism; Cell growth; Cell Line, Tumor; Cell lines; Cell nucleus; Cell Nucleus - metabolism; Cell Proliferation; Cellular metabolism; embryogenesis; Female; Gene expression regulation; Gene Expression Regulation, Neoplastic; genes; glucose; Glucose - metabolism; Glycolysis; HEK293 Cells; HeLa Cells; Histone Demethylases - metabolism; Humans; Hypoxia; hypoxia-inducible factor 1; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Isoenzymes - metabolism; isozymes; L-Lactate Dehydrogenase - metabolism; lactate dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid - metabolism; loci; MCF-7 Cells; Membrane Proteins - metabolism; metabolism; muscles; neoplasm cells; neoplasms; Neoplasms - metabolism; Protein Binding; Protein Structure, Quaternary; pyruvate kinase; secretion; Thyroid Hormone-Binding Proteins; Thyroid Hormones - metabolism; Transactivation; Transcriptional Activation; cancer metabolism; breast cancer; aerobic glycolysis; Warburg effect