Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis

• Published in: Journal of translational medicine Vol. 13; no. 1; p. 261
• Main Authors: Momen-Heravi, Fatemeh, Saha, Banishree, Kodys, Karen, Catalano, Donna, Satishchandran, Abhishek, Szabo, Gyongyi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.08.2015; BioMed Central
• Subjects: Alanine Transaminase - metabolism; Analysis; Animals; Biological markers; Biomarkers - blood; Care and treatment; Case-Control Studies; Deregulation; Diagnosis; Ethanol; Exosomes - genetics; Exosomes - metabolism; Exosomes - ultrastructure; Feeding Behavior; Female; Gene Expression Profiling; Gene Expression Regulation; Genetic aspects; Hepatitis; Hepatitis, Alcoholic - blood; Hepatitis, Alcoholic - genetics; Humans; Liver; Metabolites; Mice, Inbred C57BL; MicroRNA; MicroRNAs - blood; MicroRNAs - genetics; RNA Stability - genetics; ROC Curve; Software; Taiwan; Taiwan

It has been well documented that alcohol and its metabolites induce injury and inflammation in the liver. However, there is no potential biomarker to monitor the extent of liver injury in alcoholic hepatitis patients. MicroRNAs (miRNAs) are a class of non-coding RNAs that are involved in various phy...