Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs

• Published in: Human molecular genetics Vol. 16; no. 1; pp. 36 - 49
• Main Authors: Saccone, Scott F., Hinrichs, Anthony L., Saccone, Nancy L., Chase, Gary A., Konvicka, Karel, Madden, Pamela A.F., Breslau, Naomi, Johnson, Eric O., Hatsukami, Dorothy, Pomerleau, Ovide, Swan, Gary E., Goate, Alison M., Rutter, Joni, Bertelsen, Sarah, Fox, Louis, Fugman, Douglas, Martin, Nicholas G., Montgomery, Grant W., Wang, Jen C., Ballinger, Dennis G., Rice, John P., Bierut, Laura Jean
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.01.2007; Oxford Publishing Limited (England)
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Case-Control Studies; Chromosomes, Human, Pair 8; Cluster Analysis; Female; Fundamental and applied biological sciences. Psychology; Genetic Markers - genetics; Genetic Variation; Genetics of eukaryotes. Biological and molecular evolution; Genotype; Humans; Male; Middle Aged; Molecular and cellular biology; Polymorphism, Single Nucleotide; Receptors, Nicotinic - genetics; Tobacco Use Disorder - genetics; Cholinergic receptor; Association; Targeting; Dependence; Genetics; Candidate gene; Single nucleotide polymorphism; Nicotinic receptor; Nicotine

Nicotine dependence is one of the world's leading causes of preventable death. To discover genetic variants that influence risk for nicotine dependence, we targeted over 300 candidate genes and analyzed 3713 single nucleotide polymorphisms (SNPs) in 1050 cases and 879 controls. The Fagerström t...