Mutational spectrum and profile of breast and ovarian cancer patients in Saudi Arabia’s western region: single center experience

• Published in: Discover. Oncology Vol. 16; no. 1; pp. 829 - 15
• Main Authors: Ekram, Samar N., Elemam, Omima, Alandonisi, Munzir, Flemban, Arwa, Samkari, Jamil, Zainuddin, Hassan H., Azher, Zohor, Tashkandi, Emad, Mufti, Ahmad, Khogeer, Asim
• Format: Journal Article
• Language: English
• Published: New York Springer US 20.05.2025; Springer Nature B.V; Springer
• Subjects: BRCA1; BRCA2; Breast cancer; Cancer Research; Germline mutation; Internal Medicine; Medicine; Medicine & Public Health; Molecular Medicine; Mutation; Next-generation sequencing; Oncology; Ovarian cancer; Radiotherapy; Surgical Oncology; Womens health; Saudi Arabia; United States > US; Germany; Saudi Arabia; Germline mutation; Breast cancer; Next-generation sequencing; Ovarian cancer; BRCA1; BRCA2

Background The incidence of breast cancer (BC) and ovarian cancer (OC) has increased in Saudi Arabia. The western region of Saudi Arabia presents a unique population with distinct genetic backgrounds, making it vital to investigate the prevalence of BC/OC-associated gene mutations in this area. This...