Airways resistance and specific conductance for the diagnosis of obstructive airways diseases
Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways diseas...
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Published in | Respiratory research Vol. 16; no. 1; p. 88 |
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Language | English |
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22.07.2015
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Abstract | Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD.
976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls).
RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects.
RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases. |
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AbstractList | Background Airway resistance (R.sub.AW) and specific airway conductance (sG.sub.AW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of R.sub.AW and sG.sub.AW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results R.sub.AW and sG.sub.AW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal R.sub.AW and sG.sub.AW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sG.sub.AW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, R.sub.AW was found to be more relevant and statistically significant. In asthma patients with normal FEV.sub.1/FVC ratio, both R.sub.AW and sG.sub.AW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions R.sub.AW and sG.sub.AW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases. Keywords: Body-plethysmography, Airway resistance, Pulmonary function tests, Chronic obstructive pulmonary disease, Asthma BACKGROUNDAirway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD.METHODS976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls).RESULTSRAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects.CONCLUSIONSRAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases. Background Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). Results RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. Conclusions RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases. Airway resistance (R.sub.AW) and specific airway conductance (sG.sub.AW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of R.sub.AW and sG.sub.AW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). R.sub.AW and sG.sub.AW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal R.sub.AW and sG.sub.AW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sG.sub.AW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, R.sub.AW was found to be more relevant and statistically significant. In asthma patients with normal FEV.sub.1/FVC ratio, both R.sub.AW and sG.sub.AW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. R.sub.AW and sG.sub.AW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases. Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases. |
ArticleNumber | 88 |
Audience | Academic |
Author | Osadnik, Christian R Janssens, Wim Troosters, Thierry Decramer, Marc Topalovic, Marko Derom, Eric |
Author_xml | – sequence: 1 givenname: Marko surname: Topalovic fullname: Topalovic, Marko organization: Department of Clinical and Experimental Medicine, Laboratory of Respiratory Diseases, University Hospital Leuven, KULEUVEN University of Leuven, Herestraat 49, 3000, Leuven, Belgium – sequence: 2 givenname: Eric surname: Derom fullname: Derom, Eric organization: Respiratory Division, University Hospital Ghent, University of Ghent, Ghent, Belgium – sequence: 3 givenname: Christian R surname: Osadnik fullname: Osadnik, Christian R organization: Monash Health, Monash Lung and Sleep, Victoria, Australia – sequence: 4 givenname: Thierry surname: Troosters fullname: Troosters, Thierry organization: Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Leuven, Belgium – sequence: 5 givenname: Marc surname: Decramer fullname: Decramer, Marc organization: Department of Clinical and Experimental Medicine, Laboratory of Respiratory Diseases, University Hospital Leuven, KULEUVEN University of Leuven, Herestraat 49, 3000, Leuven, Belgium – sequence: 6 givenname: Wim surname: Janssens fullname: Janssens, Wim email: Wim.Janssens@uzleuven.be organization: Department of Clinical and Experimental Medicine, Laboratory of Respiratory Diseases, University Hospital Leuven, KULEUVEN University of Leuven, Herestraat 49, 3000, Leuven, Belgium. Wim.Janssens@uzleuven.be |
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CitedBy_id | crossref_primary_10_1002_ppul_26635 crossref_primary_10_1111_cea_13080 crossref_primary_10_1183_13993003_01585_2021 crossref_primary_10_2147_COPD_S382761 crossref_primary_10_1111_resp_14431 crossref_primary_10_3390_diagnostics11060918 crossref_primary_10_1016_j_vascn_2021_107106 crossref_primary_10_1111_resp_14463 crossref_primary_10_1136_bmjresp_2023_002142 crossref_primary_10_1186_s12906_021_03361_8 crossref_primary_10_1186_s13223_017_0226_5 crossref_primary_10_15446_revfacmed_v65n2_60938 crossref_primary_10_1016_S0140_6736_22_01273_9 crossref_primary_10_1038_s41598_018_35930_2 crossref_primary_10_2147_COPD_S319220 crossref_primary_10_1002_ajim_22717 crossref_primary_10_1371_journal_pone_0292270 crossref_primary_10_1186_s12931_016_0484_7 crossref_primary_10_22376_ijpbs_lpr_2021_11_6_L116_124 crossref_primary_10_33667_2078_5631_2021_5_57_61 crossref_primary_10_1586_17476348_2016_1155455 crossref_primary_10_2147_COPD_S384127 |
Cites_doi | 10.1201/b13346 10.2500/aap.2009.30.3194 10.1164/ajrccm.164.4.2006119 10.1016/S2213-2600(13)70184-X 10.1183/09031936.97.10061415 10.3109/15412555.2010.528087 10.1159/000193928 10.1016/S0873-2159(15)30025-8 10.1164/ajrccm.150.2.8049845 10.1183/09031936.00135909 10.1183/09031936.01.17203020 10.1172/JCI103715 10.4187/respcare.01640 10.1111/j.1365-2125.2004.02261.x 10.1183/09031936.05.00035205 10.1378/chest.111.6.1533 10.1016/j.rmed.2011.02.006 10.1002/ppul.1950080108 10.1164/rccm.200901-0127OC 10.4187/respcare.01411 10.1111/j.1440-1843.2012.02268.x 10.1172/JCI103282 10.1111/j.1440-1843.2011.01953.x 10.1136/thx.2008.103598 10.1183/09031936.05.00034805 |
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Snippet | Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these... Background Airway resistance (R.sub.AW) and specific airway conductance (sG.sub.AW) are measures that reflect the patency of airways. Little is known of the... Airway resistance (R.sub.AW) and specific airway conductance (sG.sub.AW) are measures that reflect the patency of airways. Little is known of the variability... Background Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability... BACKGROUNDAirway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability... |
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StartPage | 88 |
SubjectTerms | Adult Aged Airway Obstruction - diagnosis Airway Obstruction - epidemiology Airway Obstruction - physiopathology Airway Resistance - physiology Asthma Belgium - epidemiology Care and treatment Cohort Studies Diagnosis Female Humans Male Medical research Medicine, Experimental Middle Aged Prospective Studies Pulmonary function tests Respiratory Function Tests - methods |
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Title | Airways resistance and specific conductance for the diagnosis of obstructive airways diseases |
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