Intestinal permeability of N-acetylcysteine is driven by gut microbiota-dependent cysteine palmitoylation - Zhang, Yu-Hang; Dai, Chen-Shu; Wang, Ya-Jie; Wang, Wen-Yu; Qi, Tian-Tian; Xia, Man-Cheng; Zhou, Gan; Cui, Yi-Min (Nature communications, 2025)
Keywords: 14/19; 14/34; 49/40; 49/47; 49/90; 49/91; 59/5; 631/154/152; 631/154/436/1729; 64/86; Acetylcysteine; Acetylcysteine - metabolism; Acetylcysteine - pharmacokinetics; Animals; Bacteroides; Classification; Cysteine; Cysteine - metabolism; Drug interaction; Female; Gastrointestinal Microbiome - physiology; Germ-Free Life; Germfree; Gut microbiota; Humanities and Social Sciences; Humans; Intestinal Barrier Function; Intestinal microflora; Intestinal Mucosa - metabolism; Lipoylation; Machine learning; Male; Metabolomics; Microbiomes; Microbiota; Microorganisms; multidisciplinary; Oral administration; Palmitoylation; Perfusion; Permeability; Prediction models; Rats; Rats, Sprague-Dawley; Science; Science (multidisciplinary); Specific pathogen free; Specific Pathogen-Free Organisms