The structural and functional evidence for vesicular release from astrocytes in situ

• Published in: Brain research bulletin Vol. 136; pp. 65 - 75
• Main Authors: Bohmbach, Kirsten, Schwarz, Martin K., Schoch, Susanne, Henneberger, Christian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2018
• Subjects: Animals; Astrocytes; Astrocytes - cytology; Astrocytes - metabolism; Humans; Neurology; SNARE proteins; Synaptic Vesicles - metabolism; Transmitter release; Vesicular release; SynCAMs; VMAT; VPAT; VGluT; SNARE proteins; SNARE; RIM-BP; Nrxn1; Transmitter release; Munc; V-ATPase; RABV; Astrocytes; VAMP; BoNT; SNAP; GFAP; Syt; TeNT; RIM; AZ; Vesicular release; CAZ; VIAAT; VNUT; rabies virus; vesicular monoamine transporter; vesicular release; vacuolar-type H+-ATPase; mammalian uncoordinated; synaptosomal-associated protein; vesicular inhibitory amino acid transporter; tetanus neurotoxin; vesicular glutamate transporter; vesicular nucleotide transporter; synaptotagmin; cytomatrix at the active zone; soluble NSF attachment protein receptor; active zone; synaptic cell adhesion molecules; botulinum neurotoxin; vesicular polyamine transporter; transmitter release; regulating synaptic membrane exocytosis protein; Neurexin 1-alpha; astrocytes; glial fibrillary acidic protein; vesicle associated membrane proteins; RIM-binding protein

•The recent experimental evidence for vesicular release from astrocyte in situ is discussed.•Ultrastructural studies reveal the existence of vesicle-like structures in astrocyte.•In principle, astrocytes express the proteins/protein families implicated in vesicular release of transmitters.•Different...