Hypoxia Induces Galectin-1 Expression Via Autoinduction of Placental Growth Factor in Retinal Pigment Epithelium Cells

• Published in: Investigative ophthalmology & visual science Vol. 62; no. 2; p. 22
• Main Authors: Yamamoto, Taku, Kanda, Atsuhiro, Kase, Satoru, Ishida, Susumu
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 01.02.2021
• Subjects: Retinal Cell Biology

Galectin-1/LGALS1, a β-galactoside-binding protein, contributes to angiogenesis and fibrosis in various ocular diseases. Hypoxia-dependent and -independent pathways upregulate galectin-1/LGALS1 expression in Müller glial cells. Here, we present novel findings on the galectin-1/LGALS1 regulatory syst...