G-protein coupled receptors regulating cough

• Published in: Current opinion in pharmacology Vol. 11; no. 3; pp. 248 - 253
• Main Authors: Maher, Sarah A, Dubuis, Eric D, Belvisi, Maria G
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2011
• Subjects: Animals; bradykinin; cAMP-dependent protein kinase; cannabinoids; cough; Cough - metabolism; G-protein coupled receptors; Humans; Internal Medicine; Medical Education; nerve tissue; prostaglandins; Receptors, G-Protein-Coupled - metabolism; Sensory Receptor Cells - metabolism; Signal Transduction

► PGE 2 and bradykinin activate sensory nerves and evoke cough via the activation of EP 3 and B 2 receptors respectively. ► EP 3 and B 2 receptors mediate excitation via the TRPV1 and TRPA1 channels. ► Activation of the β 2-adrenoceptor and the CB 2 receptor inhibit vagal sensory nerve activity and...