Efficacy of a fixed combination of 0.09 % xanthan gum/0.1 % chondroitin sulfate preservative free vs polyethylene glycol/propylene glycol in subjects with dry eye disease: a multicenter randomized controlled trial

• Published in: BMC ophthalmology Vol. 16; no. 1; p. 164
• Main Authors: Pérez-Balbuena, Ana L., Ochoa-Tabares, Juan C., Belalcazar-Rey, Sandra, Urzúa-Salinas, Cristian, Saucedo-Rodríguez, Laura R., Velasco-Ramos, Regina, Suárez-Sánchez, Raúl G., Rodríguez-Carrizalez, Adolfo D., Oregón-Miranda, Aldo A.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.09.2016; BioMed Central
• Subjects: Adult; Aged; Chondroitin Sulfates - therapeutic use; Double-Blind Method; Drug therapy; Dry eye syndromes; Dry Eye Syndromes - drug therapy; Dry Eye Syndromes - metabolism; Eye Pain - drug therapy; Female; Humans; Lubricant Eye Drops - chemistry; Lubricant Eye Drops - therapeutic use; Male; Middle Aged; Ophthalmic drugs; Ophthalmology; Polyethylene glycol; Polyethylene Glycols - administration & dosage; Polysaccharides, Bacterial - therapeutic use; Preservatives, Pharmaceutical - therapeutic use; Propylene Glycol - administration & dosage; Quality of Life; Surface-Active Agents - administration & dosage; Tears - metabolism; Mexico; Tear film; Xanthan gum; Chondroitin sulfate; OSDI; Dry eye

Dry eye disease (DED) is multifactorial, affecting 5-34 % of the global adult population and reducing quality of life. The artificial tears or lubricants are the therapy most used for the treatment of DED, due to their low side effect profile, which attempt to modify the properties of the tear film....