Mechanical stimulation improves rotator cuff tendon-bone healing via activating IL-4/JAK/STAT signaling pathway mediated macrophage M2 polarization

• Published in: Journal of orthopaedic translation Vol. 37; pp. 78 - 88
• Main Authors: Liu, Yuqian, Wang, Linfeng, Li, Shengcan, Zhang, Tao, Chen, Can, Hu, Jianzhong, Sun, Deyi, Lu, Hongbin
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2022; Chinese Speaking Orthopaedic Society; Elsevier
• Subjects: IL-4/JAK/STAT signaling Pathway; Macrophage polarization; Mechanical stimulation; Original; Rotator cuff repair; Tendon-bone healing; IL-4/JAK/STAT signaling Pathway; Macrophage polarization; Mechanical stimulation; Tendon-bone healing; Rotator cuff repair

It is well known that appropriate mechanical stimulation benefits tendon-bone (T-B) healing, however, the mechanisms behind this are still uncovered completely. Here, we aimed to explore whether the IL-4/JAK/STAT signaling pathway mediated macrophage polarization was involved in mechanical stimulati...