The role of the inflammasome in cellular responses to toxins and bacterial effectors

• Published in: Seminars in immunopathology Vol. 29; no. 3; pp. 249 - 260
• Main Authors: Freche, Barbara, Reig, Núria, van der Goot, F Gisou
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.09.2007
• Subjects: Animals; Bacteria; Bacterial Infections - immunology; Bacterial proteins; Bacterial Proteins - immunology; Bacterial Toxins - immunology; Caspase 1 - immunology; Caspase 1 - metabolism; Cell surface; Cytoplasm; Double-stranded RNA; Enzyme Activation - immunology; Enzymes; Flagellin; Gram-negative bacteria; Humans; Inflammasomes; Inflammation - immunology; Innate immunity; Kinases; Lipopolysaccharides; Listeria; Mammalian cells; Models, Immunological; Multiprotein Complexes - immunology; Nod Signaling Adaptor Proteins - immunology; Nod Signaling Adaptor Proteins - metabolism; Pathogens; Phosphatase; Plasma; Salmonella; Signal Transduction - immunology; Toll-like receptors; Toll-Like Receptors - immunology; Toll-Like Receptors - metabolism; Toxins

Invading pathogens are recognized by mammalian cells through dedicated receptors found either at the cell surface or in the cytoplasm. These receptors, like the trans-membrane Toll-like Receptors (TLR) or the cytosolic Nod-like Receptors (NLR), initiate innate immunity after recognition of molecular...