Exploration of plasma exosomal miR-122-5p and its related targets KNG1 and C3 in the diagnosis of drug-resistant tuberculosis

• Published in: Scientific reports Vol. 15; no. 1; pp. 26620 - 13
• Main Authors: Yao, Xinyi, Zhang, Lahong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.07.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/2500; 692/53/2421; Adult; Anticoagulants; Automation; Biomarker; Biomarkers; Biomarkers - blood; Biopsy; Chromosome 5; Complement C3 - genetics; Complement C3 - metabolism; Complement component C3; Diagnosis; Drug resistance; Enzyme-linked immunosorbent assay; Exosome; Exosomes; Exosomes - genetics; Exosomes - metabolism; Female; Humanities and Social Sciences; Humans; Immune response; Infectious diseases; Kininogens; Liver; Male; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; miR-122-5p; multidisciplinary; Nanoparticles; Patients; Plasma; Plasma levels; Polymerase chain reaction; Proteins; Public health; Science; Science (multidisciplinary); Transmission electron microscopy; Tuberculosis; Tuberculosis, Multidrug-Resistant - blood; Tuberculosis, Multidrug-Resistant - diagnosis; Tuberculosis, Multidrug-Resistant - genetics; Well being; Western blotting; United States > US; China; Germany; Biomarker; miR-122-5p; Tuberculosis; Diagnosis; Exosome
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-025-10639-1

Drug-resistant tuberculosis (DR-TB) poses significant challenges not only to public health but also imposes substantial psychological and economic burdens on individuals and their families. As a severe infectious disease that jeopardizes both physical and mental well-being, DR-TB frequently spreads...