Short-chain Carboxylic Acid Concentration in Human Gingival Crevicular Fluid

• Published in: Journal of dental research Vol. 76; no. 1; pp. 575 - 579
• Main Authors: Niederman, R., Buyle-Bodin, Y., Lu, B.-Y., Robinson, P., Naleway, C.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.1997; SAGE PUBLICATIONS, INC
• Subjects: Acids; Aggregatibacter actinomycetemcomitans - isolation & purification; Aggregatibacter actinomycetemcomitans - metabolism; Biological activity; Butyrates - analysis; Butyric Acid; Campylobacter - isolation & purification; Campylobacter - metabolism; Carboxylic acids; Cell interactions; Cell proliferation; Colony Count, Microbial; Eikenella corrodens - isolation & purification; Eikenella corrodens - metabolism; Fusobacterium nucleatum - isolation & purification; Fusobacterium nucleatum - metabolism; Gene expression; Gingiva; Gingival Crevicular Fluid - chemistry; Gum disease; Humans; Lactic acid; periodontal disease; Periodontal diseases; Periodontal Index; Periodontitis - metabolism; Periodontitis - microbiology; Periodontium; Porphyromonas gingivalis - isolation & purification; Porphyromonas gingivalis - metabolism; Prevotella intermedia - isolation & purification; Prevotella intermedia - metabolism; Propionates - analysis; Propionic acid; short-chain carboxylic acids; Statistics, Nonparametric; Treponema - isolation & purification; Treponema - metabolism; butyric acid; short-chain carboxylic acids; periodontal disease; propionic acid

Short-chain carboxylic acids (e.g., lactic acid, propionic acid, butyric acid) are metabolic by-products of bacterial metabolism which can accumulate in the gingival crevice. It is of no small consequence, therefore, that 1- to 5-mM concentrations of these acids exhibit significant biological activi...