Low-molecular-weight anti-HIV-1 agents targeting HIV-1 capsid proteins

• Published in: RSC advances Vol. 13; no. 3; pp. 2156 - 2167
• Main Authors: Kobayakawa, Takuya, Yokoyama, Masaru, Tsuji, Kohei, Fujino, Masayuki, Kurakami, Masaki, Onishi, Takato, Boku, Sayaka, Ishii, Takahiro, Miura, Yutaro, Shinohara, Kouki, Kishihara, Yuki, Ohashi, Nami, Kotani, Osamu, Murakami, Tsutomu, Sato, Hironori, Tamamura, Hirokazu
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 06.01.2023; The Royal Society of Chemistry
• Subjects: Chemistry; Conical bodies; Hydrophobicity; Proteins; Synthesis

The HIV-1 capsid is a shell that encapsulates viral RNA, and forms a conical structure by assembling oligomers of capsid (CA) proteins. Since the CA proteins are highly conserved among many strains of HIV-1, the inhibition of the CA function could be an appropriate goal for suppression of HIV-1 repl...