Detection of moderate to high antiphospholipid antibodies by chemiluminescence meets 2023 APS classification criteria

• Published in: Scientific reports Vol. 15; no. 1; pp. 19083 - 12
• Main Authors: Jiang, Haiyue, Yang, Yaqing, Tang, Zihan, Pan, Haoyu, Liu, Honglei, Cheng, Xiaobing, Su, Yutong, Ye, Junna, Hu, Qiongyi, Meng, Jianfen, Chi, Huihui, Zhou, Zhuochao, Jia, Jinchao, Shi, Hui, Yang, Chengde, Teng, Jialin, Liu, Tingting
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.05.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250; 631/250/38; Adult; Antibodies; Antibodies, Anticardiolipin - blood; Antibodies, Anticardiolipin - immunology; Antibodies, Antiphospholipid - blood; Antibodies, Antiphospholipid - immunology; Antiphospholipid antibodies; Antiphospholipid autoantibodies; Antiphospholipid syndrome; Antiphospholipid Syndrome - blood; Antiphospholipid Syndrome - classification; Antiphospholipid Syndrome - diagnosis; Antiphospholipid Syndrome - immunology; Autoimmune diseases; beta 2-Glycoprotein I - immunology; Cardiolipin; Case-Control Studies; Chemiluminescence; Chemiluminescence assay; Classification; Clinical significance; Disease; Efficiency; Enzyme-Linked Immunosorbent Assay; Enzymes; Female; Glycoprotein I; Glycoproteins; Hospitals; Humanities and Social Sciences; Humans; IgM; Immunoassay; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunoglobulin M; Immunoglobulin M - blood; Laboratories; Luminescent Measurements - methods; Lupus; Male; Middle Aged; Morbidity; multidisciplinary; Pregnancy; Risk assessment; Risk factors; ROC Curve; Science; Science (multidisciplinary); Thrombocytopenia; Thromboembolism; Thrombosis; Antiphospholipid autoantibodies; Chemiluminescence assay; IgM; Enzyme-linked immunosorbent assay; Antiphospholipid syndrome

The 2023 ACR/EULAR criteria for antiphospholipid syndrome (APS) have modified the laboratory domain. However, enzyme-linked immunosorbent assay (ELISA) remains the sole specified method for antiphospholipid antibody detection. This study aims to establish moderate and high levels of anticardiolipin(...