Similar Elimination Rates of Glucagon-Like Peptide-1 in Obese Type 2 Diabetic Patients and Healthy Subjects

• Published in: The journal of clinical endocrinology and metabolism Vol. 88; no. 1; pp. 220 - 224
• Main Authors: Vilsbøll, T., Agersø, H., Krarup, T., Holst, J. J.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.01.2003; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Aged; Associated diseases and complications; Biological and medical sciences; Body mass index; Diabetes; Diabetes mellitus; Diabetes Mellitus - blood; Diabetes Mellitus, Type 2 - blood; Diabetes. Impaired glucose tolerance; Dose-Response Relationship, Drug; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Glucagon; Glucagon - administration & dosage; Glucagon - blood; Glucagon - pharmacokinetics; Glucagon-Like Peptide 1; Hemoglobin; Humans; Injections, Intravenous; Male; Medical sciences; Metabolic diseases; Middle Aged; Obesity; Osmolar Concentration; Peptide Fragments - administration & dosage; Peptide Fragments - blood; Peptide Fragments - pharmacokinetics; Peptides; Pharmacokinetics; Protein Precursors - administration & dosage; Protein Precursors - blood; Protein Precursors - pharmacokinetics; Reference Values; Statistical analysis; Endocrinopathy; Human; Obesity; Healthy subject; Pathophysiology; Nutrition disorder; Metabolism; Non insulin dependent diabetes; Glucagon like peptide 1; Blood plasma; Adult; Pharmacokinetics; Elderly; Nutritional status; Comparative study

We have previously shown that type 2 diabetic patients have decreased plasma concentrations of glucagon-like peptide 1 (GLP-1) compared with healthy subjects after ingestion of a standard mixed meal. This decrease could be caused by differences in the metabolism of GLP-1. The objective of this study...