Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin-like growth factor-1 in patients with acne vulgaris and their relationship with diet

• Published in: British journal of dermatology (1951) Vol. 174; no. 6; pp. 1299 - 1307
• Main Authors: Agamia, N.F., Abdallah, D.M., Sorour, O., Mourad, B., Younan, D.N.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.06.2016; Oxford University Press
• Subjects: Acne; Acne Vulgaris - etiology; Acne Vulgaris - metabolism; Adult; Case-Control Studies; Diet; Diet - adverse effects; Environmental factors; Enzyme-Linked Immunosorbent Assay; Female; Forkhead protein; Forkhead Transcription Factors - metabolism; FOXO1 protein; Growth factors; Humans; Immunohistochemistry; Insulin; Insulin-Like Growth Factor I - metabolism; Insulin-like growth factors; Life Style; Male; Rapamycin; Serum levels; Skin; Skin - metabolism; TOR protein; TOR Serine-Threonine Kinases - metabolism; Transcription factors; Young Adult

Summary Background Acne vulgaris is a multifactorial disorder of the pilosebaceous units. Several studies have reported that insulin‐like growth factor (IGF)‐1, forkhead box transcription factor (Fox)O1 and mammalian target of rapamycin (mTOR) interactions may be the key to understanding the links b...