Retention of etidronate in human, dog, and rat

• Published in: Journal of bone and mineral research Vol. 7; no. 5; p. 513
• Main Authors: Kasting, G B, Francis, M D
• Format: Journal Article
• Language: English
• Published: United States 01.05.1992
• Subjects: Adult; Animals; Bone and Bones - metabolism; Dogs; Etidronic Acid - pharmacokinetics; Female; Humans; Male; Osteoporosis - metabolism; Rats; Rats, Inbred Strains

The retention of radioactivity in human, rat, and dog following a single injected dose of radiolabeled etidronate disodium (EHDP) is shown to follow power-law decay curves with similar slopes for times up to 4, 60, and 80 days, respectively. During this period retention declines with time according...