Defective T‐cell control of Epstein–Barr virus infection in multiple sclerosis

• Published in: Clinical & translational immunology Vol. 6; no. 1; pp. e126 - n/a
• Main Authors: Pender, Michael P, Csurhes, Peter A, Burrows, Jacqueline M, Burrows, Scott R
• Format: Journal Article
• Language: English
• Published: Australia Nature Publishing Group 01.01.2017; John Wiley & Sons, Inc
• Subjects: Antigens; CD4 antigen; CD8 antigen; Cytokines; Cytomegalovirus; Cytotoxicity; Epstein-Barr virus; Flow cytometry; Histocompatibility antigen HLA; Immunoglobulin G; Infections; Interferon; Latent infection; Lymphoblastoid cell lines; Lymphocytes; Lymphocytes B; Lymphocytes T; Multiple sclerosis; Original; Peptides; Population; Proteins; Viral infections; Viruses

Mounting evidence indicates that infection with Epstein–Barr virus (EBV) has a major role in the pathogenesis of multiple sclerosis (MS). Defective elimination of EBV‐infected B cells by CD8+ T cells might cause MS by allowing EBV‐infected autoreactive B cells to accumulate in the brain. Here we und...