Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus

• Published in: Anesthesiology (Philadelphia) Vol. 123; no. 4; pp. 899 - 908
• Main Authors: Kimura, Masafumi, Suto, Takashi, Morado-Urbina, Carlos E, Peters, Christopher M, Eisenach, James C, Hayashida, Ken-Ichiro
• Format: Journal Article
• Language: English
• Published: United States Copyright by , the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc 01.10.2015
• Subjects: Analgesia - methods; Animals; Excitatory Amino Acid Transporter 2 - metabolism; Female; Glutamic Acid - physiology; Locus Coeruleus - metabolism; Male; Neuralgia - metabolism; Pain Measurement - drug effects; Pain Measurement - methods; Rats; Rats, Sprague-Dawley; Spinal Nerves - injuries; Spinal Nerves - metabolism

BACKGROUND:Patients with neuropathic pain show reduced endogenous analgesia induced by a conditioned noxious stimulus. Here, the authors tested whether peripheral nerve injury impairs descending noradrenergic inhibition from the locus coeruleus (LC) after L5–L6 spinal nerve ligation (SNL) in rats. M...