Low levels of androgens in men with erectile dysfunction and obesity
The relationship between obesity and erectile dysfunction (ED) has not been completely clarified. The aim of this study is to investigate the association between different obesity class (the World Health Organization definition) with several hormonal and instrumental parameters, in a large sample of...
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Published in | Journal of sexual medicine Vol. 5; no. 10; p. 2454 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Netherlands
01.10.2008
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Abstract | The relationship between obesity and erectile dysfunction (ED) has not been completely clarified.
The aim of this study is to investigate the association between different obesity class (the World Health Organization definition) with several hormonal and instrumental parameters, in a large sample of patients with ED.
A consecutive series of 2,435 (mean age 52.1 +/- 13.0 years) male patients with ED was investigated.
Several hormonal and biochemical parameters were studied, along with a structured interview on erectile dysfunction (SIEDY), a psychometric questionnaire (Middle Hospital Questionnaire), and penile doppler ultrasound (PDU).
Among patients studied, 41.5% were normal weight, while 42.4%, 12.1% and 4.0% showed a BMI of 25-29.9, 30-34.9 and 35 kg/m(2 )or higher, respectively. Androgen levels (including sex hormone-binding globuline bound and unbound testosterone) decreased as a function of obesity class, while luteinising hormone levels did not show any significant change. Obesity was significantly associated with a higher organic contribution to ED (as assessed by SIEDY scale 1 score), and worse PDU parameters. At multivariate linear regression analysis, after adjustment for confounders (including metabolic syndrome), low androgens remained associated with BMI, while both basal and dynamic (after prostaglandin E1 [PGE1] stimulation) peak systolic velocity (PSV) at PDU resulted significantly associated with age and elevated blood pressure (Adj. r = -0.179, -0.285 and -0.094, -0.071 for age, hypertension and for basal and dynamic PSV, respectively; all P < 0.05).
Obesity is characterized by low levels of androgens in men with ED, after adjustment for comorbidities. Obesity associated comorbidities, particularly hypertension, are the most important determinants of arteriogenic obesity-associated ED. |
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AbstractList | The relationship between obesity and erectile dysfunction (ED) has not been completely clarified.
The aim of this study is to investigate the association between different obesity class (the World Health Organization definition) with several hormonal and instrumental parameters, in a large sample of patients with ED.
A consecutive series of 2,435 (mean age 52.1 +/- 13.0 years) male patients with ED was investigated.
Several hormonal and biochemical parameters were studied, along with a structured interview on erectile dysfunction (SIEDY), a psychometric questionnaire (Middle Hospital Questionnaire), and penile doppler ultrasound (PDU).
Among patients studied, 41.5% were normal weight, while 42.4%, 12.1% and 4.0% showed a BMI of 25-29.9, 30-34.9 and 35 kg/m(2 )or higher, respectively. Androgen levels (including sex hormone-binding globuline bound and unbound testosterone) decreased as a function of obesity class, while luteinising hormone levels did not show any significant change. Obesity was significantly associated with a higher organic contribution to ED (as assessed by SIEDY scale 1 score), and worse PDU parameters. At multivariate linear regression analysis, after adjustment for confounders (including metabolic syndrome), low androgens remained associated with BMI, while both basal and dynamic (after prostaglandin E1 [PGE1] stimulation) peak systolic velocity (PSV) at PDU resulted significantly associated with age and elevated blood pressure (Adj. r = -0.179, -0.285 and -0.094, -0.071 for age, hypertension and for basal and dynamic PSV, respectively; all P < 0.05).
Obesity is characterized by low levels of androgens in men with ED, after adjustment for comorbidities. Obesity associated comorbidities, particularly hypertension, are the most important determinants of arteriogenic obesity-associated ED. |
Author | Bandini, Elisa Fisher, Alessandra D Lotti, Francesco Balercia, Giancarlo Maggi, Mario Corona, Giovanni Petrone, Luisa Mannucci, Edoardo Forti, Gianni |
Author_xml | – sequence: 1 givenname: Giovanni surname: Corona fullname: Corona, Giovanni organization: Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy – sequence: 2 givenname: Edoardo surname: Mannucci fullname: Mannucci, Edoardo – sequence: 3 givenname: Alessandra D surname: Fisher fullname: Fisher, Alessandra D – sequence: 4 givenname: Francesco surname: Lotti fullname: Lotti, Francesco – sequence: 5 givenname: Luisa surname: Petrone fullname: Petrone, Luisa – sequence: 6 givenname: Giancarlo surname: Balercia fullname: Balercia, Giancarlo – sequence: 7 givenname: Elisa surname: Bandini fullname: Bandini, Elisa – sequence: 8 givenname: Gianni surname: Forti fullname: Forti, Gianni – sequence: 9 givenname: Mario surname: Maggi fullname: Maggi, Mario |
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Snippet | The relationship between obesity and erectile dysfunction (ED) has not been completely clarified.
The aim of this study is to investigate the association... |
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SubjectTerms | Analysis of Variance Androgens - blood Body Mass Index Erectile Dysfunction - blood Erectile Dysfunction - epidemiology Erectile Dysfunction - etiology Erectile Dysfunction - physiopathology Humans Hypogonadism - blood Italy - epidemiology Linear Models Male Middle Aged Multivariate Analysis Obesity - blood Obesity - complications Obesity - epidemiology Obesity - physiopathology Psychometrics Risk Factors Severity of Illness Index Surveys and Questionnaires |
Title | Low levels of androgens in men with erectile dysfunction and obesity |
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